RESUMEN
This study was aimed to compare the anti-inflammatory calculus bovis and moschus ( C + M) with the typical steroid hydrocortisone (H) in their effects on regional ischemic myocardium. 22 anesthetized dogs were studied by the mercnry-in-Silastic length gauge and divided into Saline (S) ( n= 7 ) , C + M ( n= 8 ) and H ( n=7 ) groups. Within 3 h after occlusion of left anterior descending coronary artery (LAD), the phasic segmental length ( ASL) was reduced significantly in the II groups, indicating that regional myocardial function was improved.The amplitude of VSL in the (C + M) group, however, was not obviously changed at 1,2 and 3 h after occlusion LAD. This was identical with that of the Saline group. These results show that though C + M and H were both anti-inflammatory agents in peripheral tissues as mentioned in previous reports, C + M had no steroid effect in ischemic myocardium.