Clinical Therapeutic Efficacy of Rituximab Combined with Methotrexate on Primary Central Nervous System Lymphoma / 中国实验血液学杂志

<p><b>OBJECTIVE</b>To investigate the therapeutic efficacy of rituximab combined with methotrexate on patients with primary central nervous system lymphoma.</p><p><b>METHODS</b>Fifty eight patients with central nervous system lymphoma treated in our hospital from February 2008 to September 2011 years were randomly divided into the observation group and the control group. The control group was treated with methotrexate combined with whole brain radiotherapy; the observation group was treated by rituximab combined with methotrexate. The curative efficacy, adverse effects, life quality, and the 1 and 3 year survival rate after 2 cycles of treatment were compared between 2 groups.</p><p><b>RESULTS</b>The total effective rate of observation group was 82.76%, which significantly higher than 58.62% of the control group (P < 0.05). In observation group, the incidences of anemia, liver damage, gastrointestinal side effect and oral ulcer were significantly lower than that in control group, respectively (P < 0.05). The physiological function, physical function, health status, social and emotional function in the observation group were significantly higher than those in the control group (P < 0.05), 1 and 3 years survival rates in the observation group were 86.21% and 62.07%, significantly higher than 58.62% and 31.03% in the control group (P < 0.05).</p><p><b>CONCLUSION</b>Targeted therapy combined with chemotherapy for the primary central nervous system lymphoma can improve the patients' outcomes, reduce adverse effects, and improve the quality of life and survival rate.</p>

Preparation of self-emulsified artemisinin and its pharmacokinetics in rabbits / 第二军医大学学报

Objective: To prepare self-emulsified artemisinin and to investigate its pharmacokinetics in rabbits. Methods: The optimized formula was screened using an orthogonal experimental design, tertiary-phase diagram and solubility test; the extents of emulsification and emulsifying time were taken as the indices. The plasma concentrations of indirubin were determined by HPLC method. The crude artemisinin was taken as control and the pharmacokinetic parameters were compared between the 2 groups. Results: The artemisinin self-emulsifying drug delivery system(SEDDS) was composed of arternisinin, Tween-85, ethyloleate, and ethanol. The mean retention times (MRT) was 4. 628 h for crude artemisinin and 4. 750 h for self-emulsion. Pharmacokinetic study in rabbits demonstrated that the SEDDS of artemisinin greatly enhanced the bioavailability of artemisinin via oral administration. Conclusion: SEDDS can greatly increase the in vitro dissolution and in vivo absorption of artemisinin.