Preparation and preliminary pharmacodynamic study of rectal suppository of low molecular weight heparin / 中国生化药物杂志

Purpose　The aim is to investigate the rectal suppository of low molecular weight heparin（LMWH）.Methods　The suppository was prepared by way of heating and fusion，the drug release property was studied with the release test in vitro and the absorption of LMWH into blood was tested by the changes of rabbits blood coagulation time. Results　The drug release property in vitro followed Fick′s diffusion equation and LMWH could enter the blood through rectal medication. Conclusion　The absorption from the rectum was another route of LMWH into the blood.