Common mechanism of renin angiotensin system and nuclear factor-kappa B in acute pancreatitis / 中华急诊医学杂志

Objective Acute pancreatitis (AP) is a common acute abdomen which is widely discussed by scientists for its fast onset,acute progress and accompanied complications including SIRS and MODS.Although the therapeutic efficacy of AP was improved with the improvements in critical care,the incidence and mortality of AP remains high worldwide.The precise mechanism of AP is complicated and still controversial up to now.Recently,the regulatory mechanism of renin angiotensin system (RAS) and nuclear factor-kappa B (NF-κB) on AP has drawn attention of people.And the research could provide crucially important theoretical basis for clinical treatment.In this article,the latest research about the connection among RAS,NF-κB and AP were reviewed.