Intravenous Contrast Material Administration at High-pitch Dual-source CT Coronary Angiography: Bolus-tracking Technique with Shortened Time of Respiratory Instruction Versus Test Bolus Technique / 中国医学科学杂志(英文版)

Objective To investigate the feasibility of acquiring the similar homogeneous enhancement using bolus-tracking techniques with shortened respiratory time in prospectively electrocardiogram-gated high-pitch spiral acquisition mode (Flash mode) coronary computed tomography angiography (CCTA) compared with test bolus technique. Methods One hundred and eighty-four consecutive patients with mean heart rate ≤65 beats per minute undergoing CCTA were prospectively included in this study. The patients were randomly divided into two groups. Patients in the group A (n=92) instructed to shorten respiratory time received CCTA using bolus-tracking technique with high-pitch spiral acquisition mode (Flash mode), while those in the group B (n=92) underwent CCTA with test bolus technique. The attenuation in the ascending aorta, image noise, contrast-to-noise ratio and radiation doses of the two groups were assessed. Results There were no significant differences in the mean attenuation values in the ascending aorta (483.18±59.07 HU vs. 498.7±83.51 HU, P=0.183), image noise (21.4±4.5 HU vs. 20.9±4.3 HU, P=0.414), contrast-to-noise ratio (12.1±4.2 vs. 13.8±5.1, P=0.31) between the groups A and B. There were no significant differences in the radiation dose of dynamic monitoring scans (0.056±0.026 mSv vs. 0.062±0.018 mSv, P=0.068) and radiation dose of angiography (0.94±0.07 mSv vs. 0.96±0.15 mSv, P=0.926) between the two groups, while 15 mL less contrast material volume was administered in the group A than the group B. Conclusion Bolus-tracking technique with shortened time of respiratory in Flash mode of dual-source CT yields the similar homogeneous enhancement with less contrast material in comparison to the test bolus technique.

Association of 5-lipoxygenase expression and clinicopathological factors in colorectal carcinoma / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To examine the association of 5-lipoxygenase (5-LOX) expression with clinicopathological factors in colorectal cancer.</p><p><b>METHODS</b>Immunohistochemical stain was used to detect the 5-LOX expression in 52 resected specimens of colorectal cancer. The association between 5-LOX expression and clinicopathological factors was examined.</p><p><b>RESULTS</b>The positive rate of 5-LOX expression in 52 specimens of colorectal carcinoma was 73.1% (38/52). In 41 colorectal cancer specimens with lymph node metastasis, the positive rate of 5-LOX expression was higher than that in the specimens without metastasis (87.8% vs. 18.2%, P<0.05). The positive rate of 5-LOX expression in the specimens with deep infiltration (T3 and T4) was higher than that in the specimens with superficial infiltration (T1 and T2) (81.1% vs. 53.3%, P<0.05). The positive rate of 5-LOX expression in TNM stage III and IIII cancer was higher than that in stage I and II (79.5% vs. 53.8%, P<0.05). The positive rate of 5-LOX expression in cancers of poor differentiation and non-differentiation adenocarcinoma was higher than that of well and moderately differentiated cancer (100% vs. 50.0%, P<0.05). There were no significant differences of 5-LOX expression with tumor size,vascular invasion and peritoneal dissemination.</p><p><b>CONCLUSION</b>5-LOX expression in colorectal carcinoma is closely associated with lymph node metastasis, infiltration depth, differentiation degree and TNM stage.</p>

The significance of serum anti-titin antibodies and anti-acetylcholine receptor antibodies in patients with myasthenia gravis / 中华神经医学杂志

Objective To study the clinical significance of serum anti-Titin antibodies and thecorrelation between anti-Titin anbibodies and anti-acetyleholine receptor (AchR) antibodies in patientswith myasthenia gravis (MG). Methods We detected anti-Titin antibodies and anti-AchR antibodieswith enzyme linked immunosorbent assay (ELISA) in the sera from 81 cases of MG groups includingearly-onset MG, late-onset MG and MG with thymoma (MGT). The positive rates were compared amongthese groups. Results The positive rates of anti-Titin antibodies in sera of MG patients weresignificantly higher than controls (P<0.01). The mean titers and the positive rates of anti-Titin antibodieswere significantly higher in MGT (80%) and late-onset MG (69.4%) subgroups than in the early-onsetMG subgroup (25%). In contrast, the positive rates and mean titers of AchR antibodies in the early-onsetMG subgroup were higher than those in the late-onset MG subgroup. The detections of serum anti-Titinantibodies and AchR antibodies were consistent with the diagnosis of MG. Conclusion Anti-Titinantibodies are specific for MG. They often present in the sera of patients with MGT and late-onset MG.The positive rates and mean titers of AchR antibodies in early-onset MG patients sera are higher thanthose in late-onset MG patients. These features prompt fiu'ther studies on the pathogenesis of MG. Testingfor a combination of anti-Titin antibodies and AchR antibodies gives the higher sensitivity for thedetection of MG than each antibody alone.

Study of GRE-T_2 ~* WI MRI diagnosing microbleeding in stroke patients / 中华神经科杂志

Objective To investigate the microbleeding incidence of healthy eldery population and patients with stroke.Methods 30 cases of healthy eldery population,32 cases of cerebral hemorrhage,46 cases of patients with ischemic cerebral vascular diseases were performed of MRI and GRE-T_2 ~* WI examination.Results The microbleeding incidences was 37.5% in cerebral hemorrhage group,28.1% in multiple cerebral infarction group,25.0% in Binswanger's disease group.The most frequently seen microbleeding foci located in ganglia areas,then in thalamus areas,subcortical areas and brain stem,last in cerebellar.Conclusion GRE-T_2 ~* WI,helpful for finding microbleeding and indicating lesion degree of microblooding vessels,plays an important role in the diagnosis of stroke and decision making of treatment.