Water-soluble chemical constituents from Elaeagnus pungens leaves / 中国中药杂志

<p><b>OBJECTIVE</b>To study water-soluble chemical constituents from the leaves of Elaeagnus pungens.</p><p><b>METHOD</b>Chemical constituents of E. pungens leaves were separated by a combination of macroporous resin column chromatography, reverse phase silica gel column chromatography, Sephadex LH-20 column chromatography and semi-preparative HPLC. Their structures were identified on the basis of physicochemical properties using the spectral method.</p><p><b>RESULT</b>The two compounds were separated from E. pungens leaves and identified as kaempferol 3-O-P-D-glucopyranosyl- (1-->3)-alpha-L-rhamn-opyranosyl-(1-->6) -/3-D-galactopyranoside (1), kaempferol 3-O-P-D-glucopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (2).</p><p><b>CONCLUSION</b>Compound 2 separated from E. pungens leaves was a new compound.</p>

Preparation of water-soluble chitosan solid dispersion of daidzein / 中国中药杂志

<p><b>OBJECTIVE</b>To enhance the dissolution rate of daidzein with solid dispersion technique.</p><p><b>METHOD</b>Solid dispersions were prepared by the solvent method using water-solubility chitosan as a hydrophilic carrier. DSC, IR and X-ray methods were used to verify the formation of solid dispersion.</p><p><b>RESULT</b>Dissolution percentages of solid dispersions were more than 90 percent in the drug-carrier ratio of 1:5 and 1:9. But dissolution percentages of physical mixtures and pure drug were 40 and 38.4 percent respectively. Part of daidzein dispersed in solid dispersion in the form of microcrystalline.</p><p><b>CONCLUSION</b>Water-soluble chitosan solid dispersion can significantly increase dissolution rate of daidzein.</p>

Experiences of the Teaching on Pharmaceutics / 中华医学教育探索杂志

The purpose is to discuss the pattern of teaching,further strengthen the teaching innovation and improve the teaching quality,on the aspects of teaching contents,preparation of multimedia courseware,variety of teaching methods and establishment of teaching feedback system.

Protective Effects of Ethanol-extract of Halenia elliptica on Chemical Hepatic Injury in Mice / 中药新药与临床药理

Objective To investigate the protective effects of ethanol-extract of Halenia elliptica D. Don on chemical hepatic injury in mice. Methods Mouse models of chemical hepatic injury were induced by intraperitoneal injection of 0.12 %CCL4. Extract of Halenia elliptica D. Don by alcohol was administered,and serum ALT,AST activities and liver glycogen level were measured in mice. Results Compared with the models,the enzyme activities of ALT and AST were significantly reduced and the content of liver glycogen was significantly increased in the ethanol-ex tract of Halenia elliptica groups. Conclusion It is indicated that ethanol-extract of Halenia elliptica D. Don has an effect in protecting the liver.