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Objective:To investigate the effects of Danhong injection combined with intravenous recombinant tissue plasminogen activator (rt-PA) on cardiac function, myocardial zymogram and lipoprotein associated phospholipase A2 (Lp-PLA2) level in older adult patients with acute myocardial infarction (AMI). Methods:Eighty older adult patients with acute myocardial infarction who received treatment in Community-based General Hospital of Shaoxing Central Hospital, China between January 2017 and December 2019 were included in this study. They were randomly assigned to receive either intravenous thrombolysis with rt-PA (control group, n = 40) or Danhong injection combined with intravenous thrombolysis with rt-PA (observation group, n = 40). The changes in traditional Chinese medicine syndrome score, left ventricular ejection fraction, left ventricular end diastolic diameter, creatine kinase, creatine kinase-MB and lipoprotein associated phospholipase A2 level as well as adverse cardiovascular events were compared between the control and observation groups. Results:After treatment, the score of chest tightness, dark purple tongue, palpitation and shortness of breath in the two groups were decreased. After treatment, the score of chest tightness, dark purple tongue, palpitation and shortness of breath in the observation group was (2.13 ± 0.31) points, (1.98 ± 0.41) points, (1.77 ± 0.29) points, respectively, which was significantly lower than that in the control group [(2.98 ± 0.37) points, (2.52 ± 0.56) points, (2.13 ± 0.32) points, t = 11.137, 4.920, 5.272, all P < 0.001]. After treatment, left ventricular end diastolic diameter in each group was decreased compared with before treatment. After treatment, left ventricular end diastolic diameter in the observation group was significantly lower than that in the control group [(46.12 ± 4.11) mm vs. (49.74 ± 4.32) mm], and left ventricular ejection fraction in the observation group was significantly higher than that in the control group [(47.02 ± 3.55) % vs. (43.25 ± 4.10) %, t = 3.839, 4.396, both P < 0.001). After treatment, Lp-PLA2, creatine kinase, creatine kinase-MB levels in each group were decreased compared with before treatment. After treatment, Lp-PLA2, creatine kinase, creatine kinase-MB levels in the observation group were (171.02 ± 12.52) μg /L, (10.52 ± 2.11) U/L, (24.12 ± 3.52) U/L), respectively, which were significantly lower than those in the control group [(189.63 ± 11.98) μg/L, (14.71 ± 2.62) U/L, (32.79 ± 4.79) U/L), t = 6.792, 7.877, 9.224, all P < 0.001]. The incidence of adverse cardiovascular events in the observation group was significantly lower than that in the control group (5.00% vs. 22.50%, χ2 = 5.165, P < 0.05). Conclusion:Danhong injection combined with intravenous rt-PA for the treatment of acute myocardial infarction in older adult patients can greatly decrease traditional Chinese medicine syndrome score, improve cardiac function, regulate myocardial zymogram and Lp-PLA2 levels, and decrease the incidence of adverse cardiovascular events.
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Objective@#To investigate the effect of cephalosporin sequential therapy on acute mesenteric lymphadenitis caused by bacterial infection.@*Methods@#From December 2015 to December 2018, 66 patients with acute mesenteric lymphadenitis caused by bacterial infection in Shaoxing Central Hospital were randomly selected.The control group(33 cases) received intravenous infusion of cefuroxime.The observation group(33 cases) was treated with intravenous infusion of cefuroxime, after the abdominal pain disappeared and the peripheral blood cell count returned to normal, the cefuroxime axetil tablet was given orally.The clinical efficacy of the two groups was evaluated, and the treatment costs and adverse reactions of the two groups were counted.@*Results@#The total effective rate of the observation group was 96.97%(32/33), compared with 90.91%(30/33) of the control group, the difference was not statistically significant(χ2=1.26, P=0.53). The total cost of treatment in the observation group was (326.85±51.88)CNY, which was lower than that of the control group[(576.82±72.17)CNY], the difference was statistically significant(t=16.15, P=0.00). There were no significant adverse reactions in the two groups during treatment periods.@*Conclusion@#Sequential therapy with cefuroxime and venous infusion of cefuroxime for the treatment of acute mesenteric lymphadenitis in children with bacterial infection is safe, but sequential therapy is less expensive and therefore recommended.
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Objective@#To investigate the effect of single antiepileptic drugs(AEDs) and combination therapy on the effect of seizure after stroke, prognosis and recurrent seizures.@*Methods@#From November 2013 to December 2017, 280 patients with epilepsy and epilepsy that had been included in the epilepsy course and AEDs course for>6 months in Shaoxing Central Hospital were divided into early-onset epilepsy group and late-onset epilepsy group according to the patients' condition, with 140 cases in each group.According to different AEDs treatment regimens, they were further divided into monotherapy group(valproate) and combination therapy group(valproate, oxcarbazepine combined with levetiracetam).@*Results@#The proportion of monotherapy in the early-onset epilepsy group was significantly higher than that of the late-onset epilepsy group, and the proportion of the late-onset epilepsy group was significantly higher than that of the early-onset epilepsy group(χ2=22.857, P<0.0001). The incidence and effectiveness of epilepsy patients after single-agent and combination therapy in the early-onset epilepsy group had statistically significant differences[onset rate: 40.0%(36/90) vs.16.0%(8/50), χ2=8.591, P=0.003; effective rate: 88.9%(80/90) vs.100.0%(50/50), χ2=5.983, P=0.014]. The incidence and effectiveness of single-agent and combination therapy in the late-onset epilepsy group had statistically significant differences [seizure rate: 40.0%(20/50) vs.82.2%(74/90), χ2=25.974, P=0.000; effective rate: 64.0%(32/50) vs.87.8%(79/90), χ2=11.065, P=0.000].@*Conclusion@#The time of post-stroke epilepsy is not related with the site, type and risk factors of stroke; early epilepsy usually manifested partial seizures and had better curative effect of AEDs, and late epilepsy usually manifested overall tonic clonic seizure; there were no obvious difference in curative effect and recurrence rate of early and late epilepsy on single and combined AEDs treatment.
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To investigate the effect of cephalosporin sequential therapy on acute mesenteric lymphadenitis caused by bacterial infection.Methods From December 2015 to December 2018,66 patients with acute mesenteric lymphadenitis caused by bacterial infection in Shaoxing Central Hospital were randomly selected .The control group(33 cases) received intravenous infusion of cefuroxime.The observation group (33 cases) was treated with intravenous infusion of cefuroxime ,after the abdominal pain disappeared and the peripheral blood cell count returned to normal,the cefuroxime axetil tablet was given orally.The clinical efficacy of the two groups was evaluated , and the treatment costs and adverse reactions of the two groups were counted .Results The total effective rate of the observation group was 96.97%(32／33),compared with 90.91%(30／33) of the control group,the difference was not statistically significant(χ2 ＝1.26,P＝0.53).The total cost of treatment in the observation group was (326.85 ± 51.88)CNY,which was lower than that of the control group [(576.82 ±72.17)CNY],the difference was statistically significant(t＝16.15,P ＝0.00).There were no significant adverse reactions in the two groups during treatment periods.Conclusion Sequential therapy with cefuroxime and venous infusion of cefuroxime for the treatment of acute mesenteric lymphadenitis in children with bacterial infection is safe , but sequential therapy is less expensive and therefore recommended.
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Objective To investigate the effect of single antiepileptic drugs(AEDs) and combination therapy on the effect of seizure after stroke,prognosis and recurrent seizures.Methods From November 2013 to December 2017,280 patients with epilepsy and epilepsy that had been included in the epilepsy course and AEDs course for ＞6 months in Shaoxing Central Hospital were divided into early-onset epilepsy group and late-onset epilepsy group according to the patients' condition,with 140 cases in each group.According to different AEDs treatment regimens,they were further divided into monotherapy group(valproate) and combination therapy group(valproate,oxcarbazepine combined with levetiracetam).Results The proportion of monotherapy in the early-onset epilepsy group was significantly higher than that of the late-onset epilepsy group,and the proportion of the late-onset epilepsy group was significantly higher than that of the early-onset epilepsy group(x2 =22.857,P ＜ 0.0001).The incidence and effectiveness of epilepsy patients after single-agent and combination therapy in the early-onset epilepsy group had statistically significant differences [onset rate:40.0％ (36/90) vs.16.0％ (8/50),x2 =8.591,P =0.003;effective rate:88.9％(80/90) vs.100.0％ (50/50),x2 =5.983,P =0.014].The incidence and effectiveness of single-agent and combination therapy in the late-onset epilepsy group had statistically significant differences [seizure rate:40.0％(20/50) vs.82.2％ (74/90),x2 =25.974,P =0.000;effective rate:64.0％ (32/50) vs.87.8 ％ (79/90),x2 =1 1.065,P =0.000].Conclusion The time of post-stroke epilepsy is not related with the site,type and risk factors of stroke;early epilepsy usually manifested partial seizures and had better curative effect of AEDs,and late epilepsy usually manifested overall tonic clonic seizure;there were no obvious difference in curative effect and recurrence rate of early and late epilepsy on single and combined AEDs treatment.