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@#Objective To explore the effects of nicorandil on cardiac function and blood glucose in patients with chronic heart failure(CHF). Methods 64 patients with CHF were randomly divided into control group and treatment group. Both 2 groups received conventionaltherapy for heart failure. And the treatment group was treated with nicorandil additionally (5 mg once, 3 times a day for 12 weeks). 6-minutewalk text (6MWT), plasma N-terminal-pro brain natriuretic peptide (NT-proBNP), fasting plasma glucose (FPG), postprandial 2 hours plasmaglucose (P2hPG) and glycated hemoglobin A1c (GHbA1c) were measured before and after treatment. Results After the treatment, the6-minute walking distance and the plasma NT-proBNP levels of both groups were improved significantly (P<0.01), especially in treatmentgroup (P<0.05); the level of FPG, P2hPG and GHbA1c were not significantly different between 2 groups. Conclusion Nicorandil can effectivelyimprove the exercise tolerance of the patients with CHF, reduce the Plasma NT-proBNP level, but it has no effect on the level of bloodglucose.
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@#ObjectiveTo observe the therapeutic efficacy of L-carnitine on patients with microvascular angina (MVA).Methods48 MVA patients were divided randomly into the trail group and control group with 24 cases in each group. The patients of the trail group were treated with L-carnitine vein dropping, those of the control group took isosorbide-mononitrate orally. All treatment lasted for 12 weeks.ResultsAfter the treatment, attack times of MVA and consumption of nitroglycerin of the patients in two groups decreased obviously ( P<0.01). The time for inducing angina, the time for 0.1 mV ST segment depression, the total exercise time and ∑ST depression by exercise were improved obviously ( P<0.05). The serum total cholesterol, triglyceride and low density lipoprotein cholesterol decreased by 20.3%, 32.7% and 16.6% respectively, and high density lipoprotein cholesterol levels increased by 34.5% in the trail group ( P<0.01).ConclusionL-carnitine has affirmative effect on MVA, same as isosorbide-mononitrate.