RESUMEN
Objective To analyze the distribution features of stroke types of patients in Changde city to provide a theoretical basis for stroke prevention.Methods A total of 3594 first-onset patients from 5338 patients with stroke met the standards of Changde city center stroke registry program,chosen from 2011 January to December 2011,were used as the research object.According to the age of the patients,they were divided into 7 groups (group of 18-29 years old,group of 30-39 years old,group of 40-49 years old,group of 50-59 years old,group of 60-69 years old,group of 70-79 years old,group of elder than 80 years old); the gender ratio,incident of disease,cerebral infarction types,responsibility vascular distributions of ischemic stroke,and hemorrhagic stroke patterns of these patients were analyzed.Results Hemorrhagic stroke was noted in 864 patients (24％) and ischemic stroke in 2730 patients (76％).No significant difference on gender was noted in hemorrhagic stroke patients and ischemic stroke patients of different age groups (P＞0.05); the incident of stroke in patients of different age groups was almost the same,with an high peak level of patients elder than 60 years old.lacunar infarction and big vasogenic cerebral infarction had higher risk of incidence than other types.Patients of 40-80 years old had the highest rate of these two stokes,while other types of stoke preferred young age person.The responsible vessels were mainly located in the arterial system.Basal ganglia hemorrhage was the main type of patients of each age group; patients of 30-60 years old mainly had subarachnoid hemorrhage and patients of 40-80 years old mainly had cerebral hemorrhage.Conclusion The ischemic stroke and hemorrhagic stroke types in Changde city are basically the same as the existing research at home and abroad; single cerebral stroke risk factors may not be the same,which needs to be further studied
RESUMEN
OBJECTIVE@#To detect the expression of macrophage migration inhibitory factor(MIF) in the brain and spinal cord of chronic non-remitting model of experimental autoimmune encephalomyelitis(EAE) mouse, and to discuss their effect on EAE/MS.@*METHODS@#Seventy-two female SPF C57BL/6J mice, aged 6k8 weeks, were randomly divided into an EAE group, a blank group, and an adjuvant group. The mice were immuned by mMOG35-55 and CFA. Immunohistochemic technique was used to detect the expression of MIF in the brain and spinal cord.@*RESULTS@#In the EAE group, we observed up-regulation of MIF of central nervous system(CNS) at onset, peak and chronic phase. During each phase, the difference of MIF between the EAE group and each of the other 2 groups was significant (P<0.05). In the EAE group, the expression of MIF was the highest at the peak, which was different from other periods (P<0.05).@*CONCLUSION@#MIF significanty expressed during the procedure of EAE disease, and may be related with the onset and exacerbation of EAE.