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Chinese Journal of Cardiology ; (12): 814-818, 2010.
Artículo en Chino | WPRIM | ID: wpr-244139

RESUMEN

<p><b>OBJECTIVE</b>to investigate the combined effect of rosuvastatin (RSV) and ischemic postconditioning (PC) on myocardial ischemia-reperfusion (I/R) injury in a type 2 diabetic rat model.</p><p><b>METHODS</b>type 2 diabetic (induced by streptozotocin plus nicotinamide) rats, undergoing 30 min ischemia and 120 min reperfusion, were divided into six groups (n = 10 each): Sham, I/R without other interventions, RSV before reperfusion, PC with 3 cycles of 10 s reperfusion and 10 s ischemia, RSV + PC and RSV + PC + PI3-K inhibitor LY294002. Myocardial infarct size (IS), ultrastructural change and myocardial expression of phosphorylated eNOS/total eNOS were determined.</p><p><b>RESULTS</b>IS and ultrastructural damages were all significantly reduced and myocardial eNOS phosphorylation was significantly increased in RSV and PC groups compared with the I/R group (all P < 0.05) these beneficial effects were further enhanced by RSV + PC (all P < 0.05 vs. RSV and PC, respectively). The beneficial effects were significantly attenuated by PI3K inhibitor LY294002.</p><p><b>CONCLUSIONS</b>the results indicate that RSV + PC could alleviate myocardial ischemia-reperfusion injury in this type 2 diabetic model by activating PI3K/AKT/eNOS signaling pathway.</p>


Asunto(s)
Animales , Masculino , Ratas , Diabetes Mellitus Experimental , Diabetes Mellitus Tipo 2 , Fluorobencenos , Farmacología , Inhibidores de Hidroximetilglutaril-CoA Reductasas , Farmacología , Poscondicionamiento Isquémico , Daño por Reperfusión Miocárdica , Miocardio , Patología , Óxido Nítrico Sintasa de Tipo III , Metabolismo , Fosfatidilinositol 3-Quinasas , Metabolismo , Fosforilación , Proteínas Proto-Oncogénicas c-akt , Metabolismo , Pirimidinas , Farmacología , Ratas Wistar , Rosuvastatina Cálcica , Transducción de Señal , Sulfonamidas , Farmacología
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