RESUMEN
The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CHCl extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by HO. Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone (3) and paucatalinone A (5) were the potent anti-aging agents in the premature senescent 2BS cells induced by HO and the C-geranyl substituent may be an important factor because of its lipophilic character.
Asunto(s)
Humanos , Envejecimiento , Línea Celular , Cromatografía Líquida de Alta Presión , Flavonoides , Química , Farmacología , Frutas , Química , Peróxido de Hidrógeno , Toxicidad , Magnoliopsida , Química , Estructura Molecular , Extractos Vegetales , Química , Farmacología , Espectrometría de Masas en TándemRESUMEN
<p><b>AIM</b>To study the chemical constituents of Salsola collina Pall..</p><p><b>METHODS</b>Compounds were isolated by silica gel column chromatography. IR, MS, 1HNMR, 13CNMR, HMQC, HMBC, DEPT were used for the structural identification.</p><p><b>RESULTS</b>Two amide alkaloids were obtained. They were identified as N-transferuloyl-3-methyldopamine (I), (10bS)-1,2,3,5,6, 10b-hexahydropyrrolo [2,1-a]-8,9-dihydroxyisoquinoline-3-one (II).</p><p><b>CONCLUSION</b>Compound I was isolated from this genus for the first time. Compound II is a new compound named salsoline A.</p>