Research progress of Adenosine 5'-monophosphate-activated protein kinase in the regulation of glycolipid metabolism / 生物工程学报

Adenosine 5'-monophosphate-activated protein activated protein kinase (AMPK), a heterotrimeric complex, is an important kinase to regulate glycolipid metabolism and energy balance involved in a variety physiological processes in human body. Many research indicated that the function and activity of AMPK were closely related to inflammation, diabetes and cancers. Recent reports show that inhibition of metformin (a first-line drug) on hepatic glucose in patients with hyperglycemia is associated with AMPK pathway, suggesting that targeting AMPK may be one of the effective strategies for the prevention and treatment of a variety of chronic diseases. Here, we review research progress on the structure, activation and regulation of AMPK in glycolipid metabolism to provide an insight into the basic and clinical research of diabetes therapy.

The inhibitory effects of N-(4-carboxyphenyl)-retinamide (RA Ⅱ) on the mutagenicity of alternariol monomethyl ether / 中国病理生理杂志

0.05). Mutation frequencies induced by AME at different dosage in the presence of 15?g/ml RA Ⅱ were lower than that of AME alone (P

The effect of alternariol monomethyl ether (AME) from alternaria alternata on the lipid peroxidation in the epithelium adjacent to esophageal cancer / 中国病理生理杂志

Alternariol monomethyl ether(AME) extracted from alternaria alternata isolated from the grain in Linxian county, China. It was used to treat the cultured epithelium which was obtained from 22 patients with esophageal cancer. Vitamin E was also used to inhibit the effect of AME on the epithelium. The results showed: (1) AME was capable of increasing the malondialdehyde(MDA) content of the epithelium significantly (P