RESUMEN
Abstract Introduction: Low grade chronic inflammation can predict persons with risk of coronary heart disease [CHD] and type 2 diabetes. Women with Poly cystic ovarian syndrome [PCOS] are insulin resistant and have high risk for CHD and type 2 diabetes
Objective: Evaluate the correlation between low grade chronic inflammation and PCOS
Materials and Methods: This case-control study was done on 27 women with PCOS who were defined base on irregular menstruation and elevated androgen [clinical hyperandrogenism or hyperandrogenemia] and 27 healthy women who were matched as a control group base on similar body mass index [BMI] and age. CRP, ESR, SHBG and Testosterone were measured in all women in both groups. Determine of insulin resistance was assessed by estimation the ratio of FBS/ to Fasting insulin. The mean of testosterone, SHBG, CRP, ESR and the ratio of FBS/ to Fasting Insulin in the two groups were compared by t- test and the correlation between BMI, testosterone, SHBG and ratio of FBS/ to fasting insulin with CRP and ESR were analyzed by Pearson correlation coefficient
Results: The finding showed: the mean of CRP was significantly difference in two groups and it was more in case group. [549/67 +/- 378/38 and 2566 +/- 10/22, P<0/001]. The mean of ESR was 14/85 +/- 12/22 and 7/74 +/- 3/6 in case and control groups respectively and there was significant difference between them [P<0/007]. Also, there were significantly relation between log CRP and log ESR with BMI, there were a reversed significant relation between them and SHBG. There wasn't any relationship between log CRP and log ESR with testosteron. The collorate with FBS/Fasting Insulin and log CRP was significant and with log ESR was no significant
Conclusion: This study indicated that level of CRP and ESR in patients is higher than control group. It seems that low grade of chronic inflammation is a contributer factor to increase risk of CHD and type2 diabetes