Polyfused heterocyclic systems derived from 4-amino- 3-aryloxymethyl -5-mercapto-s-triazoles

2-aryloxymethyl-s-triazolo [5,1-benzo-[1,3] thiazine-9[H]-ones IIa-c and 1-aryloxymethyl-s-triazolo [4,3-d] [1,2,3,4] thiatriazoles IIIa-c were prepared from 4-amino-3-aryloxymethyl-5-mercapto- 1,2,4-triazoles la-c. Other new tricyclic systems; namely, 1-aryloxymethyl-s- triazolo [3,4-b] pyrrolo [1,2-d] [1,3,4] thiadiazepine derivatives IXa-c and XIa-b were synthesized by intramolecular electrophilic substitution of some 4-pyrrolyl-s- triazole derivatives. The structure of the products was established by IR and PMR spectral data

Synthesis and central nervous system activity of some novel 4 [3H] -quinazolines including thiazolo [3,2-b] -S-triazoles

Several new 2-[2,3-disubstituted thiazolo [3, 2-b]-s-triazol-5-yl] methylthio-3-aryl-4 9[3H] quinazolinones 3a-i, 4a-c and 5a-c were synthesized. Some of the products showed some CNS depressant activities

Synthesis and antihypertensive evaluation of some phthalazines containing 1,3,4-thiadiazines and 1,3,4-thiadiazin-5-ones

Starting from methyl N2[4-methylphthalazin-1-yl]dithiocarbazinate, a number of new phthalazine derivatives containing 1, 3, 4-thiadiazine and 1, 3, 4-thiadiazin-5-one rings were prepared. The structure of the new products was confirmed by spectral analysis besides synthesis via other routes. A preliminary antihypertensive evaluation revealed that most compounds possess moderate antihypertensive activity