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Context: Periodontitis is a potential risk factor for adverse pregnancy outcomes due to the presence of a subgingival load of pathogenic bacteria. Instrumentation of periodontal pockets during treatment may result in bacteremia and/or endotoxemia. Aims: The aim of this pilot clinical trial was to determine the immediate post-scaling and root planing (SRP) level of circulating endotoxin in females presenting with chronic periodontitis. Settings and Design: A before-and-after pilot clinical trial among rural women of low socioeconomic status attending the outpatient department (OPD) for periodontitis. Materials and Methods: Twenty-four women aged 25-35 years, with at least five teeth having probing depth (PD) ≥5 mm, were selected for the study. The clinical trial was divided into three phases: phase 0 (screening), phase I (just before scaling), and phase II (15 min after scaling). Phase 0, one day prior to SRP, was used to assess the eligibility of the patients and record the periodontal status. Endotoxin levels were assessed by a semiquantitiative gel-clot assay, the limulus amoebocyte lysate (Lonza®), at phase I and phase II. Statistical analysis used: The Chi-square test was used for statistical analysis. Results: There was significant increase of endotoxins levels (P<.05) immediately after scaling (15 min). Conclusions: SRP can lead to endotoxemia, possibly by release of endotoxins by bacteria of periodontal origin, into the systemic circulation.
RESUMEN
Introduction: Hyperlipidemia is a major risk factor for cardiovascular disease. Periodontal disease is caused by predominantly anaerobic gram negative bacteria. Microbial substances initiate and perpetuate the inflammation resulting in the production of high levels of proinflammatory cytokines and hyperactivity of white blood cells and of blood platelets, thus promoting the development of hyperlipidemia. Objective: To evaluate the plasma lipids (Total cholesterol, Low Density Lipoproteins and Triglycerides) as well as Fasting blood glucose levels in non diabetic, non-obese periodontal disease patients and controls. Materials and methods: 18 subjects with chronic periodontal disease (aged 38 to 50 years) were matched for age, sex and BMI (Body Mass Index) with 18 healthy subjects. Total cholesterol, low density lipoprotein, triglycerides and fasting blood glucose levels were measured using routine enzymatic biochemical methods. Results: Total cholesterol, LDL cholesterol and triglycerides was significantly higher in chronic periodontitis patients by 12 %( p<0.02), 14 %( p<0.03) and 22 %( p<0.03) respectively as compared to controls. Fasting blood glucose levels was higher by 7% (p<0.04) in chronic periodontitis patients than controls. Conclusion: Hyperlipidemia and prediabetic state may be associated with chronic periodontitis.
RESUMEN
Objectives: Attached gingiva is important for maintaining periodontium in a healthy state. The present study tries to find the normal values of width of attached gingiva in a periodontally healthy Indian population. Material and Methods: The width of attached gingiva was measured with a periodontal probe in periodontally healthy patients attending the periodontics department. Descriptive statistical analysis was done to get the mean, which will represent the normal values of width of attached gingiva for the population. Results: Female patients had a greater width than males and the 20 to 30 year old group had the greatest width of attached gingiva. The mean values of attached gingiva varied in different areas of the mouth with greatest width in maxillary central incisors and least in mandibular molars. Conclusion: Width of attached gingiva varies with age, gender and in different areas of the mouth.