Effect of aspirin and nicotinic acid derivative on hyperlipoproteinemic rabbits

The diagnosis of lipid disorders in terms of lipoprotein abnormalities is now well established and it appears that the efficacy of many hypolipidemic agents is related to the specific lipoprotein disorder being treated. The current emphasis in the field of atherosclerosis involves an evaluation of the relative contribution of individual lipoprotein5 to atherogenic potential with age and sex difference. During the course of present work the effect of aspirin is observed on the ratio of HDL, LDL on male white rabbits with usual diet for 120 days. Our result showed that aspirin significantly reduced the hyper1ipoproteinemia in treated rabbits as compared to untreated [pathological] groups of rabbits