RESUMEN
Background: Physicians are one of the most important groups directly associated with public health and their health related lifestyle has a significant impact on their patient's behaviors. Several studies showed that the majority of medical students did not have appropriate and healthy behaviors. The aim of this study was to determine the prevalence of risky lifestyle knowledge and behaviors among Shiraz medical students
Methods: This cross-sectional survey was conducted in 2011. Using a stratified random sampling method, 400 medical students were selected to fill in the questionnaires. The questionnaire contained 33 questions including demographic data, healthy lifestyle knowledge and behavior [including physical activity, fruit and vegetable consumption, water drinking, etc], perception of stress and student's health information resource. The association between demographic factors and participants' knowledge, practice and stress score was determined. The correlation between the participants' knowledge and behavior scores was calculated
Results: The mean knowledge and attitude scores were 2.8 and 3.6, respectively. In 40% of knowledge and 80% of practice questions, the percentage of the correct answer was below 50%. There was a significant correlation between the participants' knowledge and behavior scores [P<0.05]
Conclusion: This study raises the voice of concern with medical students' knowledge and behavior on healthy lifestyle measures. There is a need for re-thinking, planning and reviewing these concepts of pure reason which is essential in their future professional career. Health considerations, health surveillance and care systems which are based on evidence, reasonability and rationality still have to be paramount
RESUMEN
Multiple sclerosis [MS] is an autoimmune disease of central nerves system, in which neurological disabilities occur in young adults. Despite increasing number of studies on MS, some aspects of this disorder are still unclear. In the previous studies, it has been proven that there is direct relation between MS incidence and vitamin D deficiency. Thereby, strong evidence in MS pathogenesis suggests that endothelial cells [EC] could be harmed in MS. In addition, functional changes in EC and macrovascular injuries lead blood-brain barrier disruption in MS. Current study is the first investigation to elucidate positive influences of vitamin D against EC apoptosis in MS. Human umbilical vein endothelial cells [HUVECs] were cultured and then treated with sera from patients with active MS [in relapse] and sera from healthy volunteer participants as control group [each group n=15]. 3-[4,5-dimethylthiazol-2-yl]-5- [3-carboxymethoxyphenyl]-2-[4-sulfophenyl]-2H-tetrazolium, inner salt [MTS] assay for cell surveillance and cell-death detection kit for evaluating apoptosis were used in this study. There was a significant decrease in apoptosis rate by the serum of patients, just when 1,25[OH][2]D[3] applied before treating HUVECs with sera from active MS [in relapse]. Furthermore, the cells surveillance increased markedly with the presence of 1,25[OH][2]D[3] in culture, too. With regard to increment in EC apoptosis rate, which treated by the sera from MS patients and decrement in apoptosis rate by the presence of vitamin D in culture media, it could be proposed that vitamin D pre-treatment can be used for MS patients, due to its beneficial effects on protecting EC apoptosis