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Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (1): 67-73
en Inglés | IMEMR | ID: emr-146749

RESUMEN

Fourteen new N-acetylated and non-acetylated pyrazoline derivatives were synthesized by reacting chalcones with hydrazine in the presence of absolute ethanol however reaction was carried out in the presence of glacial acetic acid to afford N-acetylated pyrazolines. The chemical structures of the synthesized pyrazolines were confirmed by FTIR, [1]HNMR, [13]CNMR and mass spectroscopic data. The pyrazolines [1-14] were screened for antibacterial activity against ten bacterial strains using seven Gram-positive and three Gram-negative bacteria and antifungal activity against Aspergillus Flavus, Aspergillus Niger and Aspergillus pterus. Pyrazolines [1-14] found to exhibit good to excellent antimicrobial activities compared to the Levofloxacin and fluconazole used as standard drugs


Asunto(s)
Antibacterianos , Antifúngicos
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