RESUMEN
Analogy is to construct the theory of traditional Chinese medicine in clinical thinking method,which the proper use of this thinking is helpful to improve the clinical thinking of Chinese medicine,contributes to the development of disease differentiation and treatment ideas.This article tried to analyze the diagnosis and treatment of kidney diseases with Professor Zhu Zongyuan on the process,to explore the analogy on disease differentiation treatment guide.
RESUMEN
Objective:To discuss the influence of Didang Decoction on glomerulosclerosis.Methods:The glomerulosclerosis model was established by uninephrectom and injection of adriamyci,and was treated by modif ied Didang Decoction and taken western medicine Losartan as the comparison group.To observe 24-hour urinary protein and kidney function of model group and each treatment group.Reverse transcriptase Polymerase Chain Reaction(RT-PCR) was used to determine the expression of TIMP-1 and PAI-1 in each group of rats kidney tissue.Results:Didang Decoction could decline elevated 24-hour urinary protein and improve kidney function,and decline the expression of TIMP-1 and PAI-1mRNA in glomerulosclerosis rats.Conclusion:Didang decoction could delay renal failure,it may be related to the down-regulated expression of TIMP-1 and PAI-1mRNA.