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Southeast Asian J Trop Med Public Health ; 1992 Dec; 23(4): 740-4
Artículo en Inglés | IMSEAR | ID: sea-34726

RESUMEN

A two-site pan-species monoclonal antibody sandwich ELISA (MAb-MAb ELISA) was developed to detect both Plasmodium vivax and P. falciparum antigens in whole blood impregnated on filter paper. In this assay, the plates were coated with pan-species MAb 3F9 and another pan-species MAb M26-32 conjugated with alkaline phosphatase was used for detection of bound antigen. The sensitivity of this assay was 5, 10 and 10 parasites per 10(6) erythrocytes for cultured P. falciparum, patient-derived P. vivax and P. falciparum, respectively. The coincidence rates for this assay were 93% (92/99) with healthy individuals and 93% (42/45) with microscopically confirmed vivax malaria cases. After two weeks treatment, 77.7% (14/18) of vivax malaria were still positive by this assay but with diminished level of reactivities [corrected].


Asunto(s)
Animales , Anticuerpos Monoclonales , Anticuerpos Antiprotozoarios , Antígenos de Protozoos/sangre , Ensayo de Inmunoadsorción Enzimática/métodos , Humanos , Malaria Falciparum/diagnóstico , Malaria Vivax/diagnóstico , Plasmodium cynomolgi/inmunología , Plasmodium falciparum/inmunología , Plasmodium vivax/inmunología , Sensibilidad y Especificidad
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