Investigation on inhibition of HIV III B virus with extractions of Juglans regia / 中国中药杂志

<p><b>OBJECTIVE</b>To study the effect of anti-HIV III B virus with extractions from Juglans regia, so as to searching for the new and efficacious leading compound of AIDS therapy.</p><p><b>METHOD</b>Phytochemical and chromatographical techniques were used to isolate compounds from J. regia; MT4 cells and HIV III B virus were used to study the effect of anti-HIV activity in vitro. BIACORE 3000 molecule coupled equipment were used for the target research also.</p><p><b>RESULT</b>Two extractions (B&E) were isolated from J. regia which possess the effect of anti-HIV activity. Targets study found that extraction B could affected on HIV-1 gp-41 fusing protein and extraction E could affected on HIV-1 integrase respectively.</p><p><b>CONCLUSION</b>J. regia is a traditional Chinese medicine with active anti-HIV activity and worth to be studied further.</p>

Recent progress on anti-HIV research of traditional Chinese medicine and components / 中国中药杂志

This paper summarized the recent 6 years' progress of anti-HIV compounds and traditional Chinese medicines by searching international network and reviewing the domestic and foreign literature. Traditional Chinese medicinal appeared to be a rich source of potentially useful materials for the treatment of human immunodeficiency virus infection. Some of them are much more potent in anti-HIV activity. And some components extracted from the herbs are even more tonic than the crude herb medicines. It has been proved that some active components such as alkaloids, proteins, flavonoids, quercetin, terpene, lignanoid are able to work on anti-HIV. People should pay more attention to the study of traditional Chinese medicine and the leading compounds on anti-HIV/AIDS in the clinic and in the laboratory. So searching for high efficacy and low toxicity anti-HIV drug from traditional Chinese medicine is an important and prospective research direction in the future.