RESUMEN
A retrospective analysis was performed in two major HIV/AIDS referral hospitals in Beijing to evaluate the prevalence of Mycobacterium tuberculosis (MTB) and non-tuberculous mycobacterial (NTM) infections in HIV-infected patients. A total of 627 patients' data were reviewed, and 102 (16.3%) patients were diagnosed with culture-confirmed mycobacterial infection, including 84 with MTB, 16 with NTM, and 2 with both MTB and NTM. The most frequent clinical complication by mycobacterial infection was pulmonary infection (48/102, 47.1%). The overall rates of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) were 11.9% and 3.4%, respectively. This study underlines the urgent need to intensify screening for mycobacteria coinfection with HIV and to prevent the spread of drug-resistant TB among HIV-infected patients.
Asunto(s)
Adulto , Femenino , Humanos , Masculino , Infecciones Oportunistas Relacionadas con el SIDA , Epidemiología , Microbiología , Beijing , Coinfección , Tuberculosis Extensivamente Resistente a Drogas , Epidemiología , Microbiología , Infecciones por VIH , Epidemiología , Microbiología , Hospitales Urbanos , Infecciones por Mycobacterium no Tuberculosas , Epidemiología , Microbiología , Mycobacterium tuberculosis , Micobacterias no Tuberculosas , Prevalencia , Estudios Retrospectivos , Esputo , Microbiología , Tuberculosis Resistente a Múltiples Medicamentos , Epidemiología , Microbiología , Tuberculosis Pulmonar , Epidemiología , MicrobiologíaRESUMEN
70 clinical Mycobacterium tuberculosis strains isolated from AIDS patients in two HIV/AIDS referral hospitals in Beijing were used in this study. M. tuberculosis and non-tuberculosis mycobacterium (NTM) were identified by using multi-locus PCR. M. tuberculosis was genotyped by using 15-locus MIRU-VNTR technique and spoligotyping afterwards. Meanwhile, the drug susceptibilities of the strains to the four first-line anti TB drugs (rifampin, isoniazid, streptomycin, and ethambutol) and the four second-line anti-TB drugs (capreomycin, kanamycin, ofloxacin, and ethionanide) were tested with proportional method. In this study, M. tuberculosis and NTM strains isolated from AIDS patients with TB-like symptoms were identified and genotyping analysis indicated that Beijing genotype was the predominant genotype. In addition, the prevalence of drug-resistant TB, especially the prevalence of XDR-TB, was higher than that in TB patients without HIV infection.