RESUMEN
While the term atopic march has been used to imply a natural progression of a cascade of symptoms from eczema to asthma and rhinitis through childhood, this developmental profiles at an individual level are not accurate.Only a small proportion of children(7％) follow this profile.There are increasing evidences from longitudinal studies suggesting that there exist other allergic phenotypes.Through the development of internal and external mechanism of allergic disease, we could do something to help earlier diagnosis and facilitate novel approaches to disease prevention, such as human breast milk, solid food, environmental control, pharmacotherapy, etc.This review aims to summarize recently published articles in order to highlight novel research findings,clinical trial results and guidelines to assist in identifying prevention strategies to arrest the atopic march.