Expression of miR-124 and its relationship with E-cadherin and androgen receptor in triple-negative breast cancer / 实用肿瘤学杂志

Objective The objective of this study was to explore the expression of miRNA-124(miR-124)and its correlation with E-cadherin and androgen receptor(AR)in triple-negative breast cancer(TNBC).Methods The expression of miR-124 was detected by RT-PCR in TNBC tissues and adjacent normal breast tissues.The expression of E-cadherin and AR in TNBC was detected by immunohistochemistry.Results The expression of miR-124 in TNBC tissues was significantly correlated with histological grade and the expression of E-cadherin(P0.05).Conclusion In TNBC,miR-124 may play an anti-tumor effect by modulating the expression of E-cadherin.

Obervation on effect of Kanghuier transparent dressing on prevention of phlebitis induced by continous dripping of 5-fluorouracil via chemotherapy pump / 中国实用护理杂志

Objective To discuss the preventive and curative effect of Kanghuier transparent dressing on prevention of vascular and local tissure injury induced by continous dripping of 5-fluorouracil.Methods Patients(128 cases)were divided into the observation group and the control group with 64 cases in each group.Cleaning of the local skin around puncture point and use of Kanghuier transparent dressing were adopted in the observation group.The control group receivecl no vascular protective measures.The effect of phlebitis prevention was compared between the two groups.Results Statistical difference existed in the incidence rate of phlebitis between the two groups(P＜0.01),the rate of the observation group was lower than that of the control group.Conclusion Kanghuier transparent dressing can prevent the vascular and local tissure injury caused by chemotherapy for tumor patients.