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Journal of Experimental Hematology ; (6): 520-524, 2008.
Artículo en Chino | WPRIM | ID: wpr-253284

RESUMEN

This study was purposed to investigate the effects of tortois plastron, astragali, salviae miltiorrhizae and codonopsis pilosulae on gamma-globin gene synthesis in K562 cells in vitro. Benzidine staining was used to clarify the dose-and time-dependent effects of tortois plastron, astragali, salviae miltiorrhizae and codonopsis pilosulae on hemoglobin synthesis in K562 cells and Western blotting was performed to determine the level of hemoglobin F (alpha(2)gamma(2)). The results indicated that the K562 cells treated with 4 kinds of traditional Chinese medicine had different stain rates of benzidine for: 23.5% (tortois plastron), 19.8% (astragali), 15.8% (salviae miltiorrhizae) and 14.5% (codonopsis pilosulae) at 6 days after the treatment. Western blot indicated that synthesis of HbF increased. It is concluded that tortois plastron, astragali, salviae miltiorrhizae and codonopsis pilosulae enhance globins-gamma synthesis level and increase hemoglobin F level in K562 cells, the effect of which resembles that of sodium butyrate.


Asunto(s)
Animales , Femenino , Humanos , Masculino , Ratas , Astragalus propinquus , Química , Codonopsis , Química , Medicamentos Herbarios Chinos , Farmacología , Células K562 , Materia Medica , Farmacología , Ratas Sprague-Dawley , Salvia miltiorrhiza , Química , gamma-Globinas
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