Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Añadir filtros








Intervalo de año
1.
Chinese Journal of Applied Physiology ; (6): 416-420, 2010.
Artículo en Chino | WPRIM | ID: wpr-301549

RESUMEN

<p><b>OBJECTIVE</b>To investigate the diversify of the nuclear pathway of c-Jun NH2-terminal kinases (JNK) during transient brain ischemia/reperfusion injury in hippocampal neuron apoptosis in spontaneously hypertensive rats (SHR) and to test whether the neuroprotection of curcumine on transient brain ischemia/reperfusion injury in SHR is related to the nuclear pathway of JNK.</p><p><b>METHODS</b>Male Wistar-Kyoto (WKY) rats and SHR were randomly divided into five groups (n = 6): WKY sham group (W-Sham), WKY ischemia/reperfusion group (W-I/ R), SHR sham group (S-Sham), SHR ischemia/reperfusion group (S-I/R) and SHR curcumine (a chinese traditional medicine)100 mg/kg treatment group (S-Cur), which were sacrificed at 2 h, 6 h, 24 h, 3 d and 7 d after reperfusion. Global brain ischemic model was established by 4-VO method. The TdT-mediated dUTP nick end labeling (TUNEL) method was used to detect the neuron apoptosis in hippocampal CA1 region. The immunohistochemical method was applied to investigate the expressions of c-jun and c-fos in hippocampal CA1 region.</p><p><b>RESULTS</b>The expressions of apoptosis and c-jun and c-fos in CA1 region in S-Sham group, W-I/R group and S-I/R group were more than those in W-Sham group (P < 0.05), were significantly increased in S-I/R group than those in W-I/R group (P < 0.05), and were significantly decreased in S-Cur group than those in S-I/R group (P < 0.05).</p><p><b>CONCLUSION</b>Neuronal apoptosis and the expressions of c-jun and c-fos are more in SHR hippocampal. Global brain ischemia/reperfusion injury induces more expressions of apoptosis in hippocampal neuron in SHR, and the more expressions of c-jun and c-fos may participate in that process. The neuroprotection of curcumine in SHR is related to c-jun and c-fos.</p>


Asunto(s)
Animales , Masculino , Ratas , Apoptosis , Isquemia Encefálica , Metabolismo , Patología , Región CA1 Hipocampal , Metabolismo , Curcumina , Farmacología , Proteínas Quinasas JNK Activadas por Mitógenos , Metabolismo , Neuronas , Metabolismo , Proteínas Proto-Oncogénicas c-fos , Metabolismo , Ratas Endogámicas SHR , Ratas Endogámicas WKY , Daño por Reperfusión , Metabolismo , Patología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA