RESUMEN
OBJECTIVE@#To explore the association between hypoxia-inducible factor 1α (HIF-1α) expression and lymph node metastasis in oral squamous cell carcinoma (OSCC).@*METHODS@#Tumor specimens from 125 patients with histologically-proven, surgically-treated OSCC were examined by immunohistochemical staining for expression of HIF-1α. The patients were divided into two groups by the expression of HIF-1α, high expression of HIF -1α group (H-group) and low expression of HIF-1α group (L-group). The main assessment parameters were lymph node metastasis rate and disease-specific survival (DSS). The lymph node metastasis rate and clinicopathologic features were compared using Mann-Whitney test. The Kaplan-Meier curve was generated for each group and compared using the log-rank test. Cox proportional hazard models were utilized for multivariate analyses of HIF-1α expression and other baseline factors with DSS. All calculations and analyses were performed using the SPSS 17.0 software package.@*RESULTS@#The protein expression levels of HIF-1α were up-regulated in OSCC and two patients were unable to evaluate. There were 48 patients in L-group and 75 patients in H-group. Lymph node metastasis rate was 37.5% (18/48) for L-group and 58.7% (44/75) for H-group (P=0.027). Expression of HIF-1α was significantly correlated with lymph node metastasis. The patients of L-group had a significantly better DSS than the patients of H-group (70.8% vs. 46.7%, P=0.005), while the patients of L-group had a significantly better disease-free survival (DFS) than the patients of H-group (60.4% vs. 36.0%, P=0.009) by Kaplan-Meier method. A multivariate survival analysis also showed that HIF-1α expression (HR=2.164, 95%CI: 1.150-4.074, P=0.017) and T-stage (HR=1.387, 95%CI: 1.066-1.804, P=0.015) both were the independent factors associated with prognosis.@*CONCLUSION@#HIF-1α expression is significantly correlated with lymph node metastasis in OSCC. HIF-1α expression is an independent predictive factor for prognosis of OSCC patients, and may serve as a potential biomarker for molecular diagnosis and targeted therapy in future.
Asunto(s)
Humanos , Biomarcadores/metabolismo , Carcinoma de Células Escamosas/patología , Hipoxia , Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo , Inmunohistoquímica , Ganglios Linfáticos , Metástasis Linfática/genética , Neoplasias de la Boca/patología , PronósticoRESUMEN
Acinic cell carcinoma is a relatively rare salivary gland tumor predominantly occurring in the major glands. Therefore, acinic cell carcinoma rarely occurs in the mandible. In this study, a case of primary acinic cell carcinoma of the mandible was reported, and relevant literature was reviewed. The etiology, clinical symptom, image and histological features, diagnosis, treatment, and prognosis of acinic cell carcinoma in the mandible were discussed.
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Humanos , Carcinoma de Células Acinares , Diagnóstico , Mandíbula , Patología , Pronóstico , Neoplasias de las Glándulas Salivales , DiagnósticoRESUMEN
Discomfort of right eye and right maxilla region occurred after a dental implant placement in a patient who surfered stabilized osteofibrous dysplasia (OFD) of sphenoid sinus. In this article, the case was discussed and the relevant literature was reviewed. The possible causes of eye and maxilla discomfort may be associated with OFD, hyper allergic response to implant material and surgical trauma, and psychical factors as well.
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Humanos , Implantación Dental Endoósea , Implantes Dentales , Maxilar , Seno MaxilarRESUMEN
As one of the most common malignancies of the salivary glands, mucoepidermoid carcinoma had a rare frequency in mandible. A case of central mucoepidermoid carcinoma of the mandible was reported and relevant literatures were reviewed. The possible etiology, clinical symptom, radiology, histopathology, diagnosis and treatment of central mucoepidermoid carcinoma were discussed.