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Chinese Journal of Oncology ; (12): 746-748, 2004.
Artículo en Chino | WPRIM | ID: wpr-254255

RESUMEN

<p><b>OBJECTIVE</b>To evaluate the effect and toxicity of oxaliplatin combined with capecitabine (Xeloda) as a second-line chemotherapy regimen for patients with advanced gastric cancer.</p><p><b>METHODS</b>Twenty-four patients with advanced gastric cancer who had been treated by multiple chemotherapy regimens presenting poor responses were allotted. LX regimen (oxaliplatin 85 mg/m(2) in 2-hour infusion on D1 and D15, capecitabine 1250 mg/m(2)/d divided in two daily doses given from D1 to D14) was adopted. The cycles were repeated every 28 days. All patients received two or more cycles.</p><p><b>RESULTS</b>All 24 patients were evaluated after having received 2 to 6 cycles of chemotherapy, totally 92 cycles. The overall response rate was 29.2% (including 2 CR, 5 PR, 10 NC and 7 PD). The time to tumor progression (TTP) was 2 to 18 months (median 5 months), and duration of remission was 4 to 14 months (median 8 months). The major toxicities were bone marrow suppression and nausea/vomiting.</p><p><b>CONCLUSION</b>Oxaliplatin combined with capitabine is effective as a secondary line regimen for patients with advanced gastric cancer. This protocol is active and well tolerated. Further clinical studies are warranted.</p>


Asunto(s)
Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Protocolos de Quimioterapia Combinada Antineoplásica , Usos Terapéuticos , Capecitabina , Desoxicitidina , Esquema de Medicación , Fluorouracilo , Neoplasias Hepáticas , Quimioterapia , Metástasis Linfática , Náusea , Estadificación de Neoplasias , Neutropenia , Compuestos Organoplatinos , Inducción de Remisión , Neoplasias Gástricas , Quimioterapia , Patología
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