Correlation between neutrophil lymphocyte ratio and acute cerebral infarction / 医学研究生学报

Objective Cerebral infarction is characterized by high morbidity, high mortality and high disability. The aim of this study is to explore the correlation between neutrophil lymphocyte ratio and acute cerebral infarction(ACI), providing references for the prevention and treatment of ACI.Methods In this study, 111 patients with ACI admitted to the Department of Neurology of Jiangsu Provincial People′s Hospital from April 2017 to October 2017 were enrolled in the retrospective analysis and divided into 3 subgroups according to the infarct size: small area ACI group (diameter3.0 cm, n=31). A number of 107 healthy subjects were included as control group. Baseline data and blood test indicators were collected and compared between groups.Results Compared with the control group, the level of sex, smoking, drinking, hypertension, diabetes, hyperlipidemia, white blood cells, neutrophils and NLR in patients with acute cerebral infarction were higher（all P<0.05）. The white blood cell count and NLR of large area group were higher than those of small area and medium area group. The white blood cell count and NLR of large area group were higher than those of small area and middle area group, and the difference was statistically significant. Multivariate logistic regression analysis showed that smoking (OR=3.468, P=0.003), hypertension (OR=8.764, P=0.000), hyperlipidemia (OR=2.867, P=0.020), and NLR (OR=3.016, P=0.000) were risk factors for acute cerebral infarction. The area under the ROC curve of neutrophil lymphocyte ratio was 0.773, and the best diagnostic value was 2.13.Conclusion NLR is a risk factor for ACI, and has a predictive effect on the occurrence of ACI.

Effects of acupuncture on TCD and BAEP in the patient of vertebrobasilar insufficiency / 中国针灸

<p><b>OBJECTIVE</b>To explore mechanisms of acupuncture in treatment of vertebrobasilar insufficiency.</p><p><b>METHODS</b>Forty cases of vertebrobasilar insufficiency (VBI) were divided into an acupuncture group and a routine treatment group, 20 cases in each group. The acupuncture group were treated by routine treatment plus acupuncture. Transcranial Doppler ultrasonography and brain stem auditory evoked potentials (BAEP) before treatment and 2 weeks after treatment were determined to investigate the effects of acupuncture on blood flow velocity and brain electrophysiology in the patient of VBI.</p><p><b>RESULTS</b>Before treatment, the blood velocity of vertebral artery and vertebrobasilar artery at bilateral sides in the patient of VBI decreased as compared with the control group, and the abnormal rate of TCD was 75.0% (30/40) and the abnormal rate of BAEP was 70.0% (28/40), characterized with brainstem abnormality type; after treatment, the blood velocity in the two groups was improved and the abnormal rate of TCD was 47.5% (19/40), and the abnormal rate of BEAP was 45.0% (18/40). The nerve conduction of the two groups was improved, the peak latency of V wave and interpeak latency of III-V and I -V in the acupuncture group were improved significantly as compared with the routine treatment group (P < 0.05).</p><p><b>CONCLUSION</b>Acupuncture can improve the blood velocity of vertebrobasilar artery and the nerve conduction function of brainstem in the patient of vertebrobasilar insufficiency.</p>

Effect of Nimodipine on hemorrheology and BAEP in the patients with vertebrobasilar insufficiency / 中国康复理论与实践

@#ObjectiveTo observe the effect of Nimodipine on the hemorrheology and brainstem auditory evoked potentials (BAEP) in the patients with vertebrobasilar insufficiency (VBI) and to explore the mechanism.Methods50 cases with VBI were divided into Nimodipine group (25 cases) and routine therapy group (25 cases). The hemorrheology and BAEP were measured before the treatment and 1 month later.ResultsThe blood viscosity,including the whole blood viscosity shear value, plasma viscosity and blood fat of patients with VBI was increased. The total abnormity rate of BAEP was 76%. The main abnormity was brainstem type. The hemorrheology and the function of nerve conduction were improved distinctly (P<0.05) after treatment. Compared with the routine therapy group, the level of plasma viscosity was decreased markedly (P<0.05) in Nimodipine group, and peak latency of V wave, interpeak latency of III-V and I-V were also improved significantly (P<0.05).Conclusions Nimodipine can improve the hemorrheology and the function of nerve conduction in patients with VBI.