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Objective To investigate the association of COL4A2 gene polymorphism rs9521733 with lacunar stroke in Xinjiang Han populations.Methods A total of 406 Han lacunar stroke patients and 425 controls enrolled from the First Hospital of Xinjiang Medical University and the 7th Division Hospital of Xinjiang Production and Construction Corps between March 2016 and September 2017 were recruited in the study.Clinical data were collected from all subjects.The improved multiple ligase detection reaction method was used to analyze the genotypes of rs9521733 in the COL4A2 gene.SPSS 17.0 was used for data analysis.Results There was no statistically significant difference in genotype and allele frequency of rs9521733 between case group and control group.Stratification analyses showed that the CC genotype of rs9521733 was associated with a significant increase in risk of lacunar stroke in the group of age ≥≥60 years (adjusted OR =1.950,95％ CI 1.222-3.112,P =0.005).Conclusion The rs9521733 of the COL4A2 gene might be associated with a higher risk of lacunar stroke in the group of age ≥60 years.
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Objective To investigate the consequence of digital subtraction angiography (DSA) in different diseases types and inquire into the prevention of its complications. Methods the DSA results of 65 cases with cerebrovascular disease were analyzed and the relationship were observed between symptom and cerebrovascular pathology, the complications intra and after operation as well. Results Among the 65 DSA examinations, intracranial or extracraniai vascular abnormality were found in 58 cases, the positive detection rate was 89. 23% . Several subsequent coplications such as 1 case puncture site hematoma,l case angiospasm,l case epileptic attack and 1 case cerebellum infarction were observed . Conclusions DSA examination can assist in diagnosing cerebrovascular disease,it is a traumatic but reliable examination method.