RESUMEN
Objective To investigate the effect of weight management on serum HIF -1αand tumor necrosis factor α( TNF-α) in patients with obese type 2 diabetic nephropathy .Methods 180 patients with obese diabetic nephropathy were selected .According to weight management , the patients were divided into BMI increased group ( BMI compared with the basic value increased more than or equal to 3％) with 51 cases, BMI stable group ( BMI compared with the basic value changes of <3％) with 64 cases, BMI decreased group ( compared with baseline values BMI reduction of 3％) with 65 cases.The serum contents of HIF -1αand TNF-αwere measured by double antibody sandwich enzyme -linked immunosorbent assay .Results Compared with BMI decreased group ,the fasting blood glucose,glycosylated hemoglobin,postprandial 2h blood glucose in the BMI increased group and BMI stable group were increased (BMI increased group:t=10.816,17.839,12.912,BMI stable group:t=6.950,9.878,8.301, all P<0.05).Compared with the BMI stable group,the fasting blood glucose,glycosylated hemoglobin,postprandial 2h blood glucose in the BMI increased group were increased (t=5.298,8.475,5.874,all P<0.05).Compared with BMI decreased group ,the serum creatinine and blood urea nitrogen in BMI increased group and BMI stable group were increased(BMI increased group:t=13.477,27.254,BMI stable group:t=13.820,11.073,all P<0.05).Compared with the BMI stable group ,the serum creatinine and blood urea nitrogen in the BMI increased group were increased (t=6.502,14.154,all P<0.05).Compared with BMI decreased group ,the HIF-1αand TNF-αlevels of the BMI increased group and BMI stable group were elevated (BMI increased group:t=30.050,22.963,BMI stable group:t=16.261,16.476,all P <0.05).Compared with the BMI stable group,the HIF -1αand TNF -αlevels of BMI ascending group were increased(t=17.951,9.601,all P<0.05).Conclusion The serum levels of HIF -1αand TNF-αin type 2 diabetic nephropathy patients with increased BMI are significantly increased ,and the serum levels of HIF-1αand TNF-αare decreased significantly by weight management .