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OBJECTIVE:To provide reference for rational use of proton pump inhibitor(PPI)in the clinic. METHODS:In ret-rospective study,the utilization of PPI in Zhangye Municipal People’s Hospital during 2012-2014 were analyzed statistically in re-spects of consumption sum,DDDs,DDC,etc. RESULTS:The consumption sum and DDDs of PPI were increasing year by year, pantoprazole and omeprazole occupied the first and the second place in the list of consumption sum during 2012-2014. CONCU-SIONS:The consumption sum of PPI is well synchronous with their DDDs,and the application of proton pump inhibitors is reason-able basically.
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OBJECTIVE:To optimize the extraction process for Renzhi anti-cough granules.METHODS:The preparation process was optimized by orthogonal experiment design L9(33) with the amount of solvent,extraction times and concentration of alcohol as factors and with yield of paste,the latency for the cough of mice and the cough times as indexes. RESULTS:The optimum extraction process was as follows:Adding 5 times of solvent for extraction twice,and the extractum obtained was dissolved with 60% alcohol and stayed still overnight,then the supernatant was taken for filtration with ethanol-extract filtrate recovered under reduced pressure until paste was obtained,then 4 times of thoroughly mixed mixture of sugar-starch (3∶2;the starch was dried at 105 ℃ for 1 hour in advance) was added to prepare soft material,after sieving,drying and granulation,porous yellowish granules were obtained.CONCLUSION: The method can help reduce the dosage needed while enhancing drug efficacy and it is applicable for the preparation of Renzhi anti-cough granules.
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OBJECTIVE:To study the improvement of Zea mays extract on cholestatic liver diseases.METHODS: Acute cholestatic liver injury model of rat was induced by bile duct ligation and cholestatic liver model of rats was established by ANIT.Model rats were given 6.2 g?kg-1 and 3.1 g?kg-1 dose of Z.mays extract for 5 days.The content of TBIL,DBIL,ALT,AST and TBA in serum and the secretion of bile were determined.RESULTS: The corn stigma extract decreased the content of DBIL,ALT and TBA in serum of ANIT-inducing cholestatic liver model,and increased the flow and speed of bile (P