RESUMEN
Object To study the effects of chronic prenatal exposure to cocaine on hepar in the newborn rabbit at birth. Methods The pregnant Japan long ear white rabbits were divided randomly into cocaine group( N =12) and normal control( N =12). Pregnant rabbits were treated with cocaine hydrochloride 5 mg/kg or normal saline 1 ml/kg intravenously, one time daily from day 15 of pregnancy until day 30 respectively. Serum aspartate aminotransferase(AST), albumin(ALB), total bilirubin(T BIL), hepatic glutathione(GSH) were examined. Results (1)The levels of serum AST, T-BIL were significantly higher in the cocaine group than that in the control group( P
RESUMEN
0.05). The level of serum ? 2-MG and urine? 2-MG in the cocaine users(0.090?0.030)mg/L、(0.090?0.020)mg/L respectively were significantly higher than that in the controls(0.040?0.010) mg/L、(0.050?0.020)mg/L (P