RESUMEN
Copy number variations (CNVs), which can affect the role of long non-coding RNAs (lncRNAs), are important genetic changes seen in some malignant tumors. We analyzed lncRNAs with CNV to explore the relationship between lncRNAs and prognosis in bladder cancer (BLCA). Messenger RNA (mRNA) expression levels, DNA methylation, and DNA copy number data of 408 BLCA patients were subjected to integrative bioinformatics analysis. Cluster analysis was performed to obtain different subtypes and differently expressed lncRNAs and coding genes. Weighted gene co-expression network analysis (WGCNA) was performed to identify the co-expression gene and lncRNA modules. CNV-associated lncRNA data and their influence on cancer prognosis were assessed with Kaplan-Meier survival curve. Multi-omics integration analysis revealed five prognostic lncRNAs with CNV, namely
RESUMEN
Objective To investigate the clinical effect of ultrasound-guided sclerosing therapy with injection of lauromacrogol for the treatment of pelvic encapsulated hydrops. Methods A total of 40 patients with pelvic encapsulated hydrops were enrolled in this study. Under ultrasonographic guidance , puncture aspiration of pelvic encapsulated hydrops was carried out in all patients , which was followed by lauromacrogol injection of appropriate dose, and the drainage catheter was kept in the hydrops cavity. The clinical results were evaluated at one, 2 and 3 months after the treatment. Results The success rate of puncturing was 100%. Six months after the treatment, the complete cure was obtained in 86.4%of patients, and the effective rate was 100%. Conclusion For the treatment of pelvic encapsulated hydrops , ultrasound-guided sclerosing therapy with injection of lauromacrogol is effective and safe with instant result and lower recurrence rate. Therefore, this technique should be recommended in clinical practice.