RESUMEN
Objective:To study the effects of Probucol and Fosinopril on liver histological changes in type 2 diabetes mellitus. Methods: Male Wistar rats,weighing 140～160 g,were fed with chowdiet for one week,and then randomly divided into two groups:the control group (C,twelve rats)was fed with chowdiet,while another group(thirty-six rats)was fed with high-fat diet. The rats in high-fat diet group were successfully established as type 2 diabetes model four weeks later (fasting serum glucose≥7.8 mmol/l)through streptozocin (STZ)(35 mg/kg)intraperitoneal injecting,then randomly divided into three groups (twelve rats each group):Rats in Probucol group were fed with high-fat diet and Probuco(l500 mg(/kg?d),lavage);Rats in Fosinopril group were fed with high-fat diet and Fosinopri(l5.0 mg(/kg?d), lavage);Rats in simple high-fat diet group were fed with high-fat diet and water(2 ml(/one?d),lavage). Six weeks later,ratio of liver to body weight,serum ALT,AST,TG,TCHO,HDL,MDA and SOD activity,histological scoring for Nonalcoholic fatty liver disease(NAFLD) were measured respectively. Results:TCHO and ALT were significantly reduced by Probucol treatment compared with HD group (P