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In clinical follow-up studies,hazard ratio (HR) is routinely used to quantify the differences between-groups,however,it is being estimated by the Cox procedure.HR,the ratio of two hazard functions has abstract meaning only and is in lack of the context to give an intuitive explanation of the survival of patients and the assumption of proportional hazards (PH) must be satisfied.Under this context,the restricted mean survival time (RMST) can be used as a relatively effective measure or index of statistics.This paper introduces the RMST-based statistical analysis methods,including estimation of RMST and its difference,hypothesis testing and regression analysis.The application of RMST in data analysis is also introduced.All the evidence demonstrates that RMST can be used as an effective analytical tool with straightforward interpretation.RMST is also more effective than HR in comparing differences between groups,when non-PH is observed.Therefore,RMST is suggested to be stated along with HR in the process of disease efficacy evaluation and prognosis analysis.Cooperation and complement of the two,a precise reflection on the characteristics of data can be expected.
RESUMEN
In clinical follow-up studies,hazard ratio (HR) is routinely used to quantify the differences between-groups,however,it is being estimated by the Cox procedure.HR,the ratio of two hazard functions has abstract meaning only and is in lack of the context to give an intuitive explanation of the survival of patients and the assumption of proportional hazards (PH) must be satisfied.Under this context,the restricted mean survival time (RMST) can be used as a relatively effective measure or index of statistics.This paper introduces the RMST-based statistical analysis methods,including estimation of RMST and its difference,hypothesis testing and regression analysis.The application of RMST in data analysis is also introduced.All the evidence demonstrates that RMST can be used as an effective analytical tool with straightforward interpretation.RMST is also more effective than HR in comparing differences between groups,when non-PH is observed.Therefore,RMST is suggested to be stated along with HR in the process of disease efficacy evaluation and prognosis analysis.Cooperation and complement of the two,a precise reflection on the characteristics of data can be expected.
RESUMEN
Objective@#To analyze the prognostic factors on multidisciplinary team patients for diagnosis, and treatment of hepatocellular carcinoma.@*Methods@#This retrospective study enrolled 132 HBsAg positive patients with HCC. MDT diagnostic approach was conducted at our hospital between 1 January 2015 and 31 December 2015, and all patients were followed up to 31 December 2017. Groups were arranged according to variables such as Barcelona stage, MDT compliance, and multidisciplinary combination therapy. TTP and OS were statistically analyzed.@*Results@#The survival of the MDT compliance group was better than the non-compliance group. The difference in survival curves was statistically significant (χ2 = 4.062, P < 0.05). The 1- and 2-year survival rates of the former group were 72.0%, 60.9%, and the latter was 64.3%, 40.3%. The survival of the combined treatment group was better than the non-combination group. The survival curves of the two groups were statistically significant (χ2 = 9.502, P < 0.05), and they were independent influencing factors of survival (HR = 0.451, 95% CI, 0.210-0.968). The 1- and 2-year survival rates of the former group were 82.2% and 75.4%, and the latter was 63.1% and 44.6%. The median survival time of the follow-up group was 29.4 months, and the non-compliance and the uncombined group were 17.0 months. The difference was statistically significant (χ2 = 13.336, P < 0.001). The median tumor progression time was 15.7 months in the combination group and 10.1 months in the non-compliance group (χ2 = 7.263, P < 0.05).@*Conclusion@#An advanced MDT compliance with implementation of multidisciplinary combination therapy may help to improve the prognosis of MDT patients with liver cancer.
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Objective To observe the efficacy of palace production technique of Puerpera with gestational hypertension by ropivacaine combined with sufentanil and epidural anesthesia.Methods77 cases with hypertensive disorders in pregnancy from January 2014 to January 2015 hypertensive, 39 cases were randomly divided into observation group and the control group of 38 patients, the control group received ropivacaine anesthesia, the observation group received ropivacaine combined with sufentanil and epidural anesthesia, observed two groups of mothers onset time of anesthesia, operative time, pain duration, neonatal apgar score, postoperative pain scores and adverse reactions.ResultsThe onset time of anesthesia, analgesia duration, and postoperative pain scores were significantly better than the control group, the difference was significant (P<0.05);two groups of mothers in the operation time, score and adverse neonatal apgar, the total incidence the difference was not statistically significant.ConclusionRopivacaine combined with sufentanil CSEA anesthesia for hypertensive disorders in pregnancy cesarean exact effect is better than alone ropivacaine spinal anesthesia program, and no obvious side effects and is worthy of further promotion and application.