Causes and intervention measures of hypoglycemia in elderly patients after gastrointestinal polypectomy / 中华老年医学杂志

Objective:To analyze the causes of hypoglycemia in elderly patients after resection of gastrointestinal polyps.Methods:We retrospectively analyzed the data of 120 elderly patients who underwent gastrointestinal polypectomy in our hospital from November 2019 to November 2020, and analyzed the reasons for postoperative hypoglycemia.Results:(1)There were significant differences between the hypoglycemic group and the non-hypoglycemic group in age, diabetes, preoperative fluid replacement, preoperative fasting time, preoperative waiting time, preoperative emotional instability, and preoperative night sleep time(all P<0.05). (2)Logistic regression analysis showed that postoperative hypoglycemia was associated with age >70 years( OR=4.266, 95% CI: 1.120-16.162); Diabetes mellitus( OR=4.094, 95% CI: 1.311-12.773); No fluid was taken before surgery( OR=10.923, 95% CI=2.882-41.386); Preoperative fasting time ≥10 h( OR=9.042, 95% CI: 2.571-31.645); Preoperative wait time ≥12 h( OR=7.035, 95% CI: 1.855-26.651); Preoperative emotional instability( OR=4.25, 95% CI: 1.263-14.370); The preoperative night sleep time <6 h( OR=5.952, 95% CI: 1.760-19.992)was closely related(all P<0.05). Conclusions:There are many reasons for the occurrence of hypoglycemia in elderly patients after gastrointestinal polyp removal.Therefore, evaluation work should be done and preventive measures should be taken to reduce the occurrence of hypoglycemia and ensure the effectiveness and safety of treatment for patients.

Research advances in the v-raf murine sarcoma viral oncogene homolog gene mutation in ameloblastoma / 中华口腔医学杂志

V-raf murine sarcoma viral oncogene homolog B1 (BRAF) is a pro-oncogene, which is one member of the RAF family. Mutated BRAF is found in approximately 8% of human tumors. BRAF gene mutations lead to continuous activation of the mitogen-activatd protein kinase (MAPK) pathway, which resulting in abnormal cell proliferation and tumorigenesis. In recent years, recurrent MAPK signaling mutations were identified in ameloblastoma, among which BRAF-V600E is the most prominent type. This provides new strategies for the targeted treatment of ameloblastoma. This paper reviewed the latest advances in BRAF gene mutation associated with ameloblastoma and its potential clinical significance.