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Colorectal cancer is one of the common malignant tumors in China. Studies have shown that more than 50% of patients with colorectal cancer will experience metastasis. After systematic treatment, patients with resectable colorectal cancer could obtain favorable 5-year survival rate. However, patients with unresectable colorectal liver metastasis constantly obtain poor prognosis. In spite of the development of medical treatment, patients with unresectable colorectal liver metastasis can be treated by multiple approaches, such as interventional therapy combined with targeted therapy and immunotherapy, clinical efficacy is relatively low. Hence, clinicians divert extensive attention to liver transplantation. Liver transplantation, as an emerging treatment in recent years, is expected to improve clinical prognosis of patients with unresectable colorectal liver metastasis. In this article, research progress in liver transplantation for patients with unresectable colorectal liver metastasis was reviewed, mainly including the historical overview, recent results, prognostic factors, adaptation criteria, relationship with systemic treatment, liver source shortage and donor allocation, aiming to provide reference for liver transplantation for patients with colorectal liver metastasis.
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Objective:To investigate the effects of single intermittent theta-burst stimulation on functional connectivity in patients with mild cognitive impairment(MCI).Methods:From July to November 2020, forty MCI patients were selected and randomly divided into iTBS true stimulation group and iTBS sham-stimulation group, with 20 patients in each group.iTBS targeted the left dorsolateral prefrontal cortex (DLPFC). Montreal cognitive assessment (MoCA), mini-mental state examination (MMSE), activity of daily living scale(ADL), Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were evaluated at baseline.The resting state electroencephalography (rsEEG) was collected for 5 minutes before and after iTBS in the two groups.The phase lag index(PLI) of EEG functional connectivity was calculated, and the functional connectivity matrix diagram was drawn.SPSS 26.0 software was used for statistical analysis.Data were statistically analyzed by χ2 test, Wilcoxon rank sum test and independent sample t-test. Results:There were no significant differences in scores of MoCA, ADL, HAMD and HAMA between the two groups(all P>0.05). In the iTBS true stimulation group, compared with that before iTBS treatment(0.140(0.133, 0.144)), the PLI of β band increased significantly after iTBS treatment(0.146(0.136, 0.167))( P<0.05). The region of increased PLI was mainly concentrated in the central region(C3/C4-T7/T8). Compared with that before iTBS treatment(0.251(0.232, 0.299)), the PLI of α band increased after iTBS treatment(0.286(0.241, 0.359)), but the difference was not statistically significant( P>0.05). Conclusion:Single iTBS treatment can significantly increase the EEG functional connectivity in patients with MCI, indicating that iTBS targeting the left DLPFC can effectively regulate the EEG functional connectivity in patients with MCI, which may reveal the mechanism of iTBS in improving cognitive function in patients with MCI.
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Objective:To explore the effects of treadmill training during pregnancy on the development of dendritic spines and the expression of brain-derived neurotrophic factor (BDNF) in hippocampal neurons of offspring rats.Methods:According to the random number table, the natural pregnant healthy SPF female rats were divided into control group (CON group) and treadmill training group (TE group), with 6 rats in each group. The pregnant rats in CON group were fed quietly, while those in TE group were given treadmill exercise intervention 60 minutes a day with 5 days a week for 3 weeks. The setting parameters of treadmill training: the slope of electric flat plate was 0°, the track transmission speed was 8 m/min in the first 5 min, 10 m/min in the middle 25 min, and 12 m/min in the last 30 min.The body weight changes of pregnant rats in the two groups were recorded every two days from gestation of 0 day (G0). On day 21 of gestation (G21), the pregnant mice were placed in a quiet environment for labor. The expression of BDNF in hippocampus was detected by Western blot at 0, 7, 14 and 28 days after birth (P0, P7, P14, P28) respectively. The density of dendritic spines in hippocampus was detected by Golgi staining on P28. SPSS 19.0 software was used to analyze the data. Repeated measurement ANOVA was used to analyze the body weight of pregnant rats. t-test was used to analyze the data of neuronal dendritic spines. Results:Golgi staining showed that at P28, the density of dendritic spines in hippocampal CA1 area of TE group(11.330±0.558) was significantly higher than that of CON group (9.667±0.422), and the difference was statistically significant ( t=2.384, P<0.05). Compared with CON group, the relative expression level of BDNF protein in the hippocampus of offspring rats of TE group was significantly higher at P0: ((1.001±0.206), (2.027±0.240), t=3.244, P<0.05), P7: ((1.003±0.152), (2.077±0.172), t=4.669, P<0.05), P14: ((1.005±0.160), (1.562±0.178), t=3.329, P<0.05) and P28: ((1.004±0.196), (1.790±0.191), t=2.875, P<0.05), and the differences were statistically significant. Conclusion:Treadmill training during pregnancy can promote the development of dendritic spines in hippocampal neurons of offspring rats, which may be related to the promotion of BDNF expression in hippocampus.
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Military medical equipment develops rapidly in the 10th five-year-plan,but the low utilization rate still widely remains.One of the deep-seated reasons for this problem is the unreasonable element of the establishment system in military medical organization.This paper suggests reforming the military medical organization establishment system boldly,adjusting the existing power of medical service,concentrating the limited manpower & material resource and strengthening the construction of division hospital so as to fully exert the efficiency of medical equipment and improve the ability of medical service support.