RESUMEN
Objective:To assess the feasibility of dilute sulfuric acid injected into the rabbit liver in vivo,and to provide experimental proof for the interventional therapy on hepatocellular carcinoma.Methods:10 big white rabbits were randomly divided into two groups.10% sulfuric acid was injected into liver at a dose of 1ml.In the first group,the biochemical changes in serum were examined before and immediately,3,7,and 15 days after the procedure.In the second group,histopathological findings of the liver were observed after 10% sulfuric acid injected into liver immediately,3,7,15 and 30days postoperatively.Results:The ALT and AST level in serum had transient elevation,but shortly returned to the same level as before the procedure.There was no significant elevation of ALB,ALP,?-GGT,TBIL,DBIL and BUN level after the procedure.Pathological changes indicated hepatocellular degeneration,coagulative necrosis,inflammatory cells infiltration and granulation tissue proliferation.Conclusion:Diluted sulfuric acid have strong power of cells inactivation,but without obvious toxicity and side-effect,which could be a new type of tumor cells inactivation material for the treatment of hepatocellular carcinoma local ablation.