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Objective To investigate the effect of TGF? 1 on expression of MHCⅠ type antigen in human pulmonary squamous cell carcinoma.Methods Expressions of ? 2 M in primary culture cells with rhINF? and rhTGF? 1+rhINF? from human pulmonary squamous cell carcinoma were detected by FCM(Flow Cytometry Method), respectively. Results Expression of ? 2 M in all tumor cell groups was induced significantly by rhINF? ( P 0.05) Conclusion Expression of INF? induced MHCⅠ type antigen in human pulmonary squamous cell carcinoma can be inhibited by TGF? 1.
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This paper is to report the result of the surgical treatment of 12 cases of carcinoma of the hypopharynx and cervical esophagus in a period of 3 years.Ten out of the 12 cases were explored and resection of the tumor was perforr med on 8 cases. In 7 cases out of the 8. the esophagus was stripped out and the stomach was transposed without thoracotomy and total pharyngolaryngectomy was performed in addition on 3 of them. In the 8th resected case, the pharynx, larynx and the cervical esophagus were resected and then a segment of jejunum was isolated ar.d transplanted to reconstruct an esophagus.All the cases stood the operation rather well. Postoperatively 3 cases developed serious complications; one died of cardiac failure, one developed salivary fistula and the third one developed partial ischemic necrosis of the transposed stomach. The last patient was treated with intraluminal intubation and he could take soft food when he was discharged. Six cases were followed up for years;two died one year after operation and 4 are living.The operative indications, the method of approach, and the postoperative complications were discussed. It is concluded that carcinoma of the hypopharynx and cervical esophagus is not an uncommon disease with high resectability and better survival rate as compared with carcinomas of other sites, but early detection and prompt operation are imperative for a cure.
RESUMEN
Objective To investigate the expression of TGF ? 1 in human pulmonary squamous cell carcinoma Methods TGF ? 1 in serum free conditioned medium of different differentiated degree primary cells in culture from human pulmonary squamous cell carcinoma were detected by ELISA Results TGF ? 1 in serum free conditioned medium from all tumor cell groups is significantly higher than from normal bronchial epithelial cell groups ( P 0 05) Conclusion Inhibition effect by TGF ? 1 on cell growth of human pulmonary squamous cell carcinoma is weakened