RESUMEN
Epigenetics is the study of heritable traits that are not involved in the changes in DNA sequences.It has been widely recognized that epigenetics plays multiple regulatory roles in diverse cellular activities and is associated with the occurrence and development of a variety of diseases.Following the human genome project (HGP),discoveries in the field of epigenetics reveal the complexity and accuracy of genetic regulation.Institute of Biomedical Sciences (IBS),which is affiliated with Fudan University Shanghai Medical School,has been attaching great importance to "Medical Epigenetics" since the establishment of IBS.In the past 12 years,a number of influential discoveries in medical epigenetics have been made,raising China's status in the field of epigenetics and contributing greatly to the disciplinary construction and talent cultivation of biomedical-related disciplines in Fudan University.In this review,a list of accomplishments in epigenetics in IBS were summarized.