Effects of intrathecal ketamine on the expression of pCREB in the spinal cord of morphine tolerant rats / 上海第二医科大学学报

0.05) in tail flick test.MPE% in group MK was always higher than group M and descended more slowly than group M,especially from the d4 to d8(P0.05). Conclusion Ketamine could block the development of morphine tolerance partly due to its inhibition effect on pCREB protein.