RESUMEN
AIM To investigate the clinical therapeutic effects and pulmonary function effects of phentolamine combined with Dangshen Bufei Decoction (Astragali Radix,Codonopsis Radix,Atractylodis macrocephalae Rhizoma,etc.) in the treatment of asthmatic disease in infants.METHODS From August 2013 to April 2016,94cases of infants with asthmatic disease in our hospital for diagnosis and treatment were selected and randomly divided into observation group of 47 cases and control group of 47 cases.The control group was given phentolamine treatment,while the observation group was treated with phentolamine combined with Dangshen Bufei Decoction.Two groups were both treated for seven days.RESULTS The total effective rates in the observation group and the control group were 97.9％ and 85.1％,respectively,the total effective rate in the observation group was significantly higher than that in the control group (P ＜ 0.05).The total disappearance time of dyspnea,cough,fever and other symptoms in the observation group were significantly faster than those in the control group (P ＜ 0.05).The incidence rate of facial flushing,irritability,bradycardia,nausea,vomiting and other adverse reactions in the observation group was 17.0％,which was 19.1％ in the control group,there was no significant difference between the two groups (P ＞0.05).CD4 + values in the observation group and the control group after the treatment were significantly lower than those before the treatment (P ＜ 0.05),while CD8 + values were significantly higher than those before the treatment (P ＜ 0.05).After the treatment,CD4 + and CD8 + values in the observation group showed significant statistical differences as compared with those in the control group (P ＜ 0.05).FVC values in the observation group and the control group after the treatment were (83.55 ± 15.29)％ and (75.20 ± 11.49)％,respectively,which were significantly higher than those before the treatment [(68.24 ± 15.20)％ and (69.01 ± 14.03)％,respectively] (P ＜0.05),and FVC value in the observation group was also significantly higher than that in the control group (P ＜ 0.05).CONCLUSION Phentolamine combined with Dangshen Bufei Decoction has good safety in the treatment of asthmatic disease in infants,which can improve clinical symptoms and immune function,so as to promote the improvement of lung function and therapeutic effects.