Significance of Detection of CD4~+ CD_(25)~(high) Regulatory T Cells in Children with Juvenile Idiopathic Arthritis / 实用儿科临床杂志

Objective To investigate the potential role of CD4+CD25high in the generation of juvenile idiopathic arthritis(JIA).Methods Expression of CD4 and CD25 on T cells in peripheral blood and synovial fluid were examined by flow cytometry,and the FoxP3 expression was detected through intracellular staining.Peripheral blood from 7 healthy children matched in age and gender served as normal control.Results Compared with normal control,there were increased number of CD4+CD25high T cell in JIA synovial fluid which expressed high level FoxP3,but decreased number in peripheral blood.Conclusion Accumulation of natural regulatory T cells in local tissue of JIA may contribute to the pathological process of such disease.