1.
Journal of China Pharmaceutical University
;
(6): 440-444, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-615033
RESUMEN
Eight 1,6-O,O-diacetylbritannilactone (OABL) derivatives (compounds 1-8) were synthesized by esterification or reduction of 1-O-diacetylbritannilactone (ABL) isolated from Inula japonica.All derivatives were evaluated for their anti-inflammation activities through the determination of inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced macrophages.As results,compounds 5-8 (IC50 < 2 μmol/L) exhibited more potent inhibition of NO production activities than the lead compound OABL.