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Laboratory Animal Research ; : 45-53, 2014.
Artículo en Inglés | WPRIM | ID: wpr-124667

RESUMEN

Pig pancreas may be a therapeutic resource for human diabetic patients. However, this potential is hindered by a lack of knowledge of the molecular events of pig pancreas development. In this study, the embryonic day 60, neonate and 6-month protein profiles of pig pancreas were ascertained at using two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-time of flight mass spectrometry. Twenty four proteins were differentially expressed during pig pancreas development. Among them, 12 spots increased and 7 spots decreased according to development. The expression of 5 protein were highest at birth. Expression of digestive enzymes including trypsin, pancreatic triacylglycerol lipase and pancreatic alpha-amylase was elevated in adults, whereas chymotrypsins were highly expressed in neonates. Proteins that were abundantly expressed during gestation were alpha-1-antitrypsin, alpha-fetoprotein and transferrins. Taken together, we found out that several proteins were significantly up- or down- regulated from pig pancreas based on developmental stage. This study will provide basis for understanding development of pig pancreas.


Asunto(s)
Adulto , Humanos , Recién Nacido , Embarazo , alfa-Amilasas , alfa-Fetoproteínas , Quimotripsina , Electroforesis , Electroforesis en Gel Bidimensional , Lipasa , Espectrometría de Masas , Páncreas , Parto , Sus scrofa , Transferrina , Transferrinas , Tripsina
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