The sutureless circumcision – an alternative to the standard technique.

Introduction: Circumcision is a commonly performed surgery. Surgeons have become increasingly interested in the use of adhesive bonds. Recent advances have been made in the use of tissue glu in the circumcision. In this study, we used 2-octul cyanoacrylate for closing circumcision wounds and we have reported our experience. Material & Methods: this was a prospective non-prospective preliminary clinical study involving 30 patients where 2-octyl cyanoacrylate was used as a tissue adhesive for wound closure after formal formal circumcision at of our department. Result: In this study, there is significant less pain. There is 10% (3 cases) of complication are observed. The wound cosmesis score on 90th post-operative day is optimal except in one patient of woud separation. Conclusion: The comparison with criterions of time taken for skin closure.

Use of topical skin adhesive (2-octyl cyanoacrylate) following circumcision surgery.

Introduction: circumcision is a commonly performed surgery. Surgeons have become increasingly interested in the use of adhesive bonds. Recent advances have been made in the use of tissue glue in the circumcision. In this study, we used 2-octyl cyanoacrylate for closing circumcision wounds and we have reported our experience. Material & Methods: this was a prospective non-comparative preliminary clinical study involving 30 patients where 2-octyl cyanoacrylate was used as a tissue adhesive for wound closure after formal circumcision at surgery department, Smt S.C.L. Municipal General Hospital from May 2008 to Nov 2010. Result: in this study, the mean time taken for skin closure by 2-octyl cyanoacrylate is much faster in last year of study. There is significant less pain. There is 10% (3 cases) of complications are observed. The wound cosmesis score on 90th post-operative day is optimal except in one patient of wound separation. Conclusion: the comparison with criterions of time taken foe skin closure, the post-operative pain, the cosmetic appearance of adhesive glue proves that 2-octyl cyanoacrylate skin closure is significantly better than the traditional skin suturing skin closure.

Comparison of tensile strength of Fibrin Glue,­ 2-Octyl Cyanoacrylate, liquid ocular bandage, and conventional nylon 10-0 sutures in corneal laceration repair in an animal model

Objective@#To compare the tensile strength of fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage to conventional nylon 10-0 sutures in sealing central linear corneal lacerations.@*Methods@#An experimental in-vitro study was performed on 74 porcine eyes. A 27-gauge needle connected to an infusion system with balanced salt solution was inserted into the anterior chamber and the bottle height was adjusted accordingly. Full-thickness central corneal lacerations were created using a 3.2 mm keratome knife for the initial incision and enlarged by a 5.2 mm knife. The wounds were sealed with fibrin glue (Tisseel®), 2-octyl cyanoacrylate (Dermabond®), liquid ocular bandage (OcuSeal™), and nylon 10-0 with 3 sutures. Tensile strength of the wounds was measured by recording the bottle height above the level of the porcine eyes before leakage was detected and this was converted to IOP values. One-way ANOVA and post hoc t-test were used to analyze the data.@*Results@#Mean maximum IOP where leakage was resisted for the nylon 10-0 suture group was 52.37 ± 7.16 mm Hg. The mean maximum resisted IOP for the fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage was 46.34 ± 12.64 mm Hg, 55.13 ± 10.46 mm Hg, and 56.99 ± 8.27 mm Hg respectively. There was no significant difference between the sutures and all of the adhesives groups (p=0.08, p=0.34, and p=0.08) and between 2-octyl cyanoacrylate and liquid ocular bandage (p=0.57). 2-Octyl cyanoacrylate and liquid ocular bandage demonstrated higher mean IOP as compared to the fibrin group (p = 0.024 and p = 0.007).@*Conclusion@#Fibrin glue, 2-octyl cyanoacrylate, and liquid ocular bandage were shown to be effective in sealing 5.2 mm linear corneal lacerations, with 2-octyl cyanoacrylate and liquid ocular bandage being superior to the fibrin glue.

Nailbed Repair using 2-octyl Cyanoacrylate (Dermabond(R))

PURPOSE: Nailbed repair using fine 6-0 or 7-0 absorbable sutures can be technically demanding and time-consuming. We describe a simpler method of nailbed repair using 2-octyl cyanoacrylate (Dermabond(R)) topical adhesive. MATERIALS AND METHODS: Fifteen consecutive patients with nailbed injuries not involving the germinal matrix were repaired with Dermabond(R). There were 7 simple lacerations, 4 stellate lacerations and 4 severe crush injury according to Zook's classification. The appearance of the nail at twelve months was graded according to ridging, splitting, deformity, and sheen of the nail. RESULTS: Nailbed repairs using Dermabond(R) took on average 3.2 minutes to complete. Six patients had excellent aesthetic results, Eight had good results, and one patient with a crush injury had a fair result. There were no complications. CONCLUSION: Dermabond(R) is a useful tool for rapidly repairing acute nailbed injuries. The outcome of repairing injuries not involving the germinal matrix is similar to that expected for suture repairs of similar injuries.

Evaluación de la histotoxicidad del 2-octyl-cyanoacrilato en el cerebro del conejo / Histotoxicity evaluation of 2-octyl-cyanoacrylate on the rabbit's brain

The aim of the present study was to evaluate the effect of the 2-octyl-cyanoacrylate, on a rabbit's brain. The study was undertaken to investigate the histological behavior of the brain with this synthetic tissue adhesive. We evaluated a total of 12 rabbits, wich were randomized into 2 groups of 6 rabbits each. Following fronto-temporo-parietal craniectomy, 1 cm of the cranium was removed and the dura mater was 0,5 cm sectioned. In the control group, dura mater was sutured with 6-0 polypropylene interrupted sutures. In the study group, the brains were covered by using 2-octyl-cyanoacrylate (high viscosity), before closurewith 6-0 polypropylene suture. Rabbits were sacrificed on day 7 following operation. Integrity of the sutures, existence of abscess, wound infection and adhesion formation were recorded. The heads were removed including the site of operation and then, the specimens were sent for histological examination. Mean weights of each study group increased. The body temperatures of the animals were normal in the two groups. The histopathological evaluation of the brains treated with the synthetic glue revealed 50 per cent of inflammatory response with focal necrosis in the cortex. Only one rabbit had a normal brain. Results under experimental conditions, indicate that this new substance, 2-octyl-cyanoacrylate, can not be considered as safe supportive material for intradural procedures directly involving the brain tissue.