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Objective To investigate the value of 4D-CTA combined with SDF-1a/CXCR4 signaling pathway in evaluating the risk of intracranial aneurysm rupture.Methods Fifty patients with unruptured intracranial posterior communicating aneurysms and 50 patients with ruptured intracranial posterior communicating aneurysms were divided into unruptured group 1 and ruptured group 1.All patients underwent 4D-CTA examination and serumSDF-1alevel was detected.Non-ruptured group 1 was followed up for 12 months(After conservative treatment),on this basis,patients with ruptured posterior communicating aneurysms were included in ruptured group 2,and patients with unruptured posterior communicating aneurysms were included in non-ruptured group 2.Results The AUC values of Wn,AR,L,SR,SDF-1a and their combinations in diagnosing ruptured intracranial posterior communicating aneurysms were all greater than 0.70.The AUC values of Wn,AR,L,SR,SDF-1a and their combinations in predicting ruptured intracranial posterior communicating aneurysms in ruptured group 2 were all greater than 0.70.Conclusion 4D-CTA combined with SDF-1acan effectively distinguish ruptured intracranial posterior communicating aneurysms and predict the risk of rupture.
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Objective To explore the correlation between 4D-CTA imaging and the risk factors for the rupture of anterior communicating aneurysms.Methods A total of 100 patients with anterior communicating aneurysms in the Department of Radiology of Yan'an Hospital of Kunming City from June 2020 to March 2023 were selected as the study objects.The patients were divided into ruptured group and unruptured group based on whether the aneurysm had ruptured(with 50 cases in each group).The unruptured group(50 cases)received conservative treatment and follow-up observation for 1-12 months.The measurements included the aneurysm neck width(Wn),aneurysm height(H),average diameter of the carrying artery(DA),aneurysm length(L),aneurysm neck ratio(AR),the ratio of aneurysm height to carrying artery diameter(SR),aneurysm volume to aneurysm base area(VOR),and the search for the pulsation point of the aneurysm,analyzing the correlation between these measurements and aneurysm rupture.Results Wn,AR,L and SR in ruptured group 1 were higher than those in non-ruptured group 1(P<0.05).Wn,AR,L and SR in fracture group 2 were higher than those in non-fracture group 2(P<0.05).The CT values of internal carotid artery and middle cerebral artery,and the CT values and noise of brain parenchyma in 4D-CTA were higher than those in 3D-CTA(P<0.05).Conclusion The use of 4D-CTA imaging for quantitative analysis of anterior communicating aneurysms can not only predict the risk of rupture,but also provide better image quality compared to 3D imaging while reducing radiation dosage.4D-CTA imaging has a positive impact on the diagnosis and treatment of clinical aneurysms.