Real World Evidence of Bempedoic Acid on Efficacy and Safety in Patients with Uncontrolled LDL-c and at High Risk of CVD

Background and Objective: Cardiovascular disease (CVD) is a significant cause of morbidity and mortality worldwide, with high-risk patients requiring effective management to reduce their risk of cardiovascular events. Bempedoic acid is a novel therapeutic agent recently approved as an add-on therapy to statins in patients with uncontrolled LDL-c. Bempedoic acid inhibits cholesterol synthesis in the liver, which ultimately reduces the risk of cardiovascular events. Therefore, the present study aims to assess the efficacy and safety of bempedoic acid in patients with uncontrolled LDL-c (Previously on moderate or high-intensity statins) with a high risk of CVD in real-world settings. Methods: This is a multicenter, retrospective, observational study on the data of high-risk-CVD patients collected from Bempedoic Acid on Efficacy and Safety in patients (BEST) Registry. The clinical data of 140 patients who were already on statin therapy and were receiving Bempedoic acid at a dose of 180 mg, along with measurements of the level of LDL-c, HbA1c, HDL, TG, TC, PPPG, FPG, AST, ALT, serum creatinine was taken into consideration. The primary outcome includes a change in LDL-c level, and secondary outcomes involve a change in the level of HbA1c, HDL, TG, TC, PPPG, FPG, AST, ALT, and serum creatinine at week 12 and 24. Adverse events were reported at both time points. Results: A total of 140 patients were included in the present study with a mean age of 51.8 ± 9.2 years and had primary confirmed diagnosis of dyslipidemia with uncontrolled LDL-c. The mean levels of LDL-c decreased from the mean baseline value of 142.67 ± 46.49 mg/dL, to 106.78 ±33.92 mg/d; a statistically significant reduction by 23.23% (p < 0.01) at week 12. Similarly, at week 24, the mean LDL-c value reduced to 90.39 ± 38.89 mg/dL. A 33.38 % decrease was observed (p < 0.01). Other parameters such as non-HDL, FPG, PPPG, AST and serum creatinine also showed statistically significant reduction at week 12 and week 24. Conclusion: The present study demonstrates that bempedoic acid is an effective add-on medication in lowering LDL-c levels in high-risk CVD patients with uncontrolled LDL-c.

Synovium and blood capillaries at the femoral attachment of anterior cruciate ligament are significantly abundant than those at the tibial attachment / Sinovial y capilares sanguíneos en la inserción femoral del ligamento cruzado anterior son significativamente más abundantes que los de la inserción tibial

SUMMARY: The anterior cruciate ligament (ACL) is a ligament that mainly controls the anterior and rotational mobility of the knee joint, and its surface is covered by a synovial membrane with large number of blood vessels. In general, nutritional supply to the ligament is from many capillaries in the adjacent synovium. However, statistical studies of the capillaries distributed to the ACL are insufficient. In this study, we examined cross-sectional histological images of the femoral attachment (femoral level), middle level of the tendon (middle level), and tibial attachment (tibial level) of the ACL and statistically analyzed blood capillary distribution among the three levels. The ACLs of 10 cadavers were divided into 5 equal sections, and 4mm-thick paraffin sections were made at the femoral level, middle level, and tibial level, and then hematoxylin-eosin (HE) staining were performed. The area of each transverse section was measured using Image-J 1.51n (U. S. National Institutes of Health, Bethesda, MD, USA). Fiber bundles of the ACL were relatively small and sparse in cross-sectional area at the femoral level and became larger and denser toward the tibial level. Many blood levels. The synovium at the attachment of ACL covered the surface of the fiber bundle and also penetrated deeply between the fiber bundles. In particular, the blood capillaries were densely distributed in the synovium at the femoral attachment rather than another two levels. Indeed, the number of capillaries were also most abundant in the femoral level. The cross-sectional ACL area at the femoral level is significantly small, however, the blood capillaries were most abundant. Therefore, when the ACL is injured, its reconstruction with preservation of the femoral ligamentous remnant may be clinically useful for remodeling of the grafted tendon.

El ligamento cruzado anterior (LCA) es un ligamento que controla principalmente la movilidad anterior y rotacional de la articulación de la rodilla, y su superficie está cubierta por una membrana sinovial con gran cantidad de vasos sanguíneos. En general, el suministro de nutrientes al ligamento proviene de muchos capilares en la sinovial adyacente. Sin embargo, los estudios estadísticos de los capilares distribuidos en el LCA son insuficientes. En este estudio, examinamos imágenes histológicas trans- versales de la inserción femoral (nivel femoral), el nivel medio del tendón (nivel medio) y la inserción tibial (nivel tibial) del LCA y analizamos estadísticamente la distribución de los capilares sanguíneos entre los tres niveles. Los LCA de 10 cadáveres se dividieron en 5 secciones iguales y se realizaron cortes en parafina de 4 µm de espesor a nivel femoral, medio y tibial, y luego se realizó tinción con hematoxilina-eosina (HE). El área de cada sección transversal se midió utilizando Image-J 1.51n (Institutos Nacionales de Salud de EE. UU., Bethesda, MD, EE. UU.). Los haces de fibras del LCA eran relativamente pequeños y escasos en el área de la sección transversal a nivel femoral y se hicieron más grandes y más densos hacia el nivel tibial. La membrana sinovial en la unión del LCA cubría la superficie del haz de fibras y también penetraba profundamente entre entre los haces de fibras. En particular, los capilares sanguíneos estaban densamente distribuidos en la unión femoral de la sinovial respecto a los otros dos niveles. De hecho, el número de capilares también fue más abundante a nivel femoral. El área transversal del LCA a nivel femoral era significativamente pequeña, sin embargo, los capilares sanguíneos fueron los más abundantes. Por lo tanto, cuando hay una lesión del LCA su reconstrucción con preservación del ligamento femoral remanente puede ser clínicamente útil para remodelar el tendón injertado.

Arthroscopic fixation of chronic bicruciate tibial avulsion fractures: A case report / 中华创伤杂志(英文版)

A cruciate ligament avulsion is a much less common form of injury than a cruciate ligament tear. Simultaneous tibial avulsion fractures of both cruciate ligaments occur even more rarely. Over the last decades, many studies have described arthroscopic fixation of acute cruciate tibial avulsion fractures, but arthroscopic treatment in a late presenting patient has not been reported in the literature. This case report presents a 32-year-old female with a chronic tibial avulsion fracture of both anterior cruciate ligament and posterior cruciate ligament. Simultaneous fixation of both fractures was performed arthroscopically at week four post-injury. At one year of follow-up, the patient had demonstrated full knee range of motion and stable knee with no complaints, and achieved excellent clinical outcomes. Radiographs showed union of both fractures, and the patient had resumed high-impact exercises.

Comparison of Outcomes Between All-Inside SingleBundle and Double-Bundle Anterior Cruciate Ligament Reconstruction: A Retrospective Study

@#Introduction: ACL rupture is the most common type of knee injury. The All-inside ACL reconstruction procedure features some distinguished components including closed-socket tunnels with less bone expulsion, double suspensory fixation, and smaller incisions. We aimed to compare the outcomes between the All-inside Single-bundle and the Double-bundle ACL reconstruction techniques. Materials and methods: This study was a retrospective study which analysed the patient-reported and the clinical outcomes on patients who underwent ACL reconstruction between January and December 2020 at Dr Kariadi General Hospital Semarang, Indonesia. We compared the patientreported and the clinical outcomes at 6- and 12-month follow-ups between the All-inside Single-bundle and the Double-bundle groups. The patient-reported outcomes were determined using the IKDC and Tegner-Lysholm scores while the clinical outcomes included the measurement of Thigh Circumference, Single Hop test, Anterior Drawer test, Lachman test, Range of motion, and the patient’s level of return to sport. Results: A total of 24 subjects were divided into two groups, namely the All-inside Single-bundle and the Double-bundle groups, consisting of 12 subjects in each group. Most of the subjects were male in both groups, including 9 (75%) subjects in the All-inside Single-bundle group, and 11 (91.67%) subjects in the Double-bundle group. The mean age of the subjects were 25.75±7.57 years old in the Allinside Single-bundle group, and 24.5±6.87 years old in the Double-bundle group. In terms of the side of the knee that suffered the most injuries in both groups were the right knees. The result of the patient-reported outcomes using IKDC and Tegner-Lysholm scores showed no statistically significant differences in both groups at 6- and 12-month follow-ups (p=0.864; p=0.293 and p=0.589; p=0.233, respectively). The results of clinical assessments at 6- and 12-month follow-ups also showed no statistically significant differences in both groups. Conclusion: Our study showed no significant differences in the patient-reported and the clinical outcomes between the All-inside Single-bundle and the Double-bundle ACL reconstruction techniques at 6- and 12-month follow-ups.

Effectiveness of ultrasound guided platelet rich plasma injection in comparison with standard conservative treatment on improving pain and function among the athletes with partial anterior cruciate ligament injury of knee: a randomized controlled trial

Background: Anterior cruciate ligament (ACL) injuries are one of the most common ligamentous injuries of knee. Treatment options for partial ACL tear range from conservative treatment up to partial reconstruction. PRP may have enhancing effect on ACL cell viability and promotion of cell proliferation in partial tear of ACL. Thus, the purpose of this study is to determine the role of PRP on partial ACL tear.Methods:A RCT was done among athletes with partial ACL injury who visited department of Sports Medicine, RIMS, Imphal during June 2019-December 2020. Patients with MRI diagnosed grade 1 and 2 ACL injury (n=48) randomized into PRP injection plus rehabilitation, (n=24) and rehabilitation alone, (n=24) groups. The outcomes were compared using International Knee Documentation Committee (IKDC) score, Lysholm score and VAS at baseline, 1stmonth, 4thmonth, 8thmonth and 12thmonth respectively.Results: Baseline characteristics were not statistically significant.At the end of 1stmonth, there were statistically significant improvement in both mean difference of IKDC score (.001), Lysholm score (0.001) and VAS (0.007). At the end of 4thmonth, there were statistically significant improvement in both mean difference of IKDC score (0.001), Lysholm score (0.026) and VAS (0.001). At the end of 8thand 12thmonth, improvement in mean difference of IKDC score, Lysholm score, VAS were observed however not statistically significant.Conclusions: Ultrasound guidedPRP injection along with conservative rehabilitation program might be a treatment choice for ACL partial tear.

Comparative Study of Arthroscopic Anterior Cruciate Ligament Reconstruction by Quadrupled Semitendinosus-Gracilis and Tripled Semitendinosus Auto Graft

Background: The anterior cruciate ligament (ACL) is the most frequently disrupted ligament of the knee. Arthroscopic ACL reconstruction is one of the most common orthopaedic procedures now-a-days and has become the gold standard method of treatment in complete ACL tear. Though the choice of graft for ACL reconstruction and the methods of its fixation are matters of debate, hamstring tendon is considered as the favorable graft. Common options for the choice of graft are quadrupled semitendinosus-gracilis and tripled semitendinosus auto graft. Aim of our study is to compare the outcome of arthroscopic ACL reconstruction by quadrupled semitendinosus-gracilis and tripled semitendinosus auto graft.Material & Methods:In this prospective interventional study purposive sampling was done. Sixty patients with complete ACL tear were included in this study from May 2017 to August 2019 at NITOR, strictly considering the inclusion and exclusion criteria. Thirty of them treated with quadrupled semitendinosus-gracilis (group 1) and thirty with tripled semitendinosus (group 2) auto graft. Evaluation by Lysholm knee score was done before and after surgery. Final outcome was evaluated at 24th week post-operatively.Results:Preoperative Lysholm Knee Score was almost similar in group 1 (63.2�1) and in group 2 (63.1�5). This difference was not statistically significant (p=0.582). Postoperative Lysholm Knee Score at 24th week was slightly higher in group 1 (95.0�0) in comparison to group 2 (94.4�2). This difference was also not statistically significant (p=0.361). But excellent functional outcome was more in group 1 (80.0%) in comparison to group 2 (73.3%) whereas no poor or fair outcome was reported in group 1 but fair outcome was reported in 6.7% of patients in group 2. Overall complication rate was 6.67% with no significant intergroup difference.Conclusions:Quadrupled semitendinosus-gracilis auto graft has yielded more excellent results than tripled semitendinosus graft. But as this difference was not significant, it can be said that, both the procedure can be performed for arthroscopic reconstruction of ACL.

Avaliação isocinética da força de contração excêntrica dos músculos isquiotibiais no período pré-operatório de pacientes com lesão de ligamento cruzado anterior / Isokinetic assessment of eccentric hamstring strength in the preoperative period of patients with anterior cruciate ligament injury

Introdução: A força de contração excêntrica é uma moderna medida para definir diferentes parâmetros no estudo da Ortopedia moderna, sendo considerada uns dos recentes temas mais discutidos no quesito ganho de força muscular. O objetivo do trabalho foi analisar o estado da musculatura flexora da coxa (isquiotibiais), através da avaliação de sua força de contração excêntrica, por meio do dinamômetro isocinético no período pré-operatório nos pacientes com lesão de ligamento cruzado anterior. Métodos: Estudo retrospectivo observacional entre agosto e dezembro de 2018 de uma clínica especializada em atendimento em Criciúma/SC. Resultados: A média do pico de torque excêntrico da musculatura posterior da coxa em flexão do membro afetado foi de 27,60 ± 10,56 kg, e do membro contralateral atingiu 27,47 ± 6,91 kg. O déficit de força entre os membros teve uma mediana de 9,14 % (0,0 - 61,45), e o tempo médio entre a lesão e o exame isocinético foi de 10,0 (1,0 - 48,0) meses. Observou-se que os maiores déficits de força foram encontrados naqueles indivíduos que tinham maior intervalo de tempo entre a lesão e a realização da avaliação isocinética. Conclusão: Nos indivíduos submetidos ao teste de dinamometria isocinética após lesão do ligamento cruzado anterior, evidenciou-se um déficit na força de contração excêntrica da musculatura isquiotibial entre o membro afetado e contralateral, o que ratifica achados da literatura a respeito da biomecânica articular do joelho. Além disso, maiores déficits foram encontrados naqueles pacientes com maior intervalo de tempo para realização do exame isocinético.

Introduction: Eccentric strength is a modern measurement for defining different parameters in the study of modern orthopaedics, being considered one of the most widely discussed topics in recent times within the subject of muscle strength gain. The aim of this work was to analyze the state of flexor muscles in the thigh (hamstring muscles) by evaluating their eccentric strength with an isokinetic dynamometer during the preoperative period of patients with anterior cruciate ligament injury. Methods: This is a retrospective observational study performed between August and December 2018 at a specialized clinic in Criciúma/SC. Results: The mean eccentric peak torque of the hamstring muscles during flexion of the affected limb was 27.60 ± 10.56 kg and that for the contralateral limb was 27.47 ± 6.91 kg. The strength deficit between limbs had a median value of 9.14% (0.0­61.45) and the mean time between the injury and isokinetic testing was 10.0 (1.0­48.0) months. Higher strength deficits were observed in individuals who had longer periods between the injury and isokinetic testing. Conclusion: In individuals who underwent isokinetic testing after an anterior cruciate ligament injury, there was a deficit between the eccentric hamstring strength of the affected limb and that of the contralateral limb, which corroborates findings in the literature regarding the biomechanics of the knee joint. Moreover, larger deficits were found in patients with longer periods between the injury and isokinetic testing.

Anterior Cruciate Ligament (ACL) Reconstruction and Extra-Articular Tenodesis in a Contralateral Above-Knee Amputee Following Complex Trauma: A Case Report

@#We report the outcome following arthroscopic ACL reconstruction combined with a Modified LeMaire procedure in a patient who underwent multiple surgeries following an open ipsilateral femoral fracture and an above knee amputation of the contralateral limb at the time of initial trauma. This case highlights the importance of achieving ligamental stability in the contra-lateral limb in aiding proper rehabilitation following amputation and the potential pitfalls of retrograde femoral nailing.

Cross-Cultural Adaptation and Measurement Properties of the Indonesian Kujala Score for Anterior Cruciate Ligament Tear Patients

@#Introduction: There is an overwhelming need for worldwide applicable subjective grading systems for patients' anterior cruciate ligament (ACL) tear. The scoring system should be validated for their use in advance related measurements. For the Indonesian language speaking population, only the Kujala Patellofemoral Score (KPS) questionnaire has been translated and validated into the Indonesian language for diseases related to knee pain, but none for ACL tears. The present study aims at cross-cultural adaption to measure the validity and reliability of the Kujala patellofemoral score Indonesian version (KPS-I) specifically for ACL tear patients. Material and methods: The responses of 106 ACL tear patients on two questionnaires comprising the KPS-I and Short Form (SF)–36 were examined by determining the validity and reliability. We conducted the validity construct and content, so the reliability was evaluated by test-retest reliability, internal consistency and measurement error. In addition, the research utilised the Bland and Altman method to explore absolute agreement. Results: The construct and content validity were good, where all hypotheses were confirmed, and the floor or ceiling effect did not occur. The reliability proved excellent between test and retest (ICC=0.99). An internal consistency showed a good Cronbach α of 0.86. The standard error of measurement (SEM), minimal detectable change at the individual (MDCind), and minimal detectable change at the group (MDCgrp) were determined to be 2.1, 5.8, and 0.7, respectively. The application of the Bland and Altman plot method revealed no bias in this study. Conclusion: The validation procedure shows that the KPS-I is a good evaluation instrument for Indonesian patients with ACL tear. However, it is suggested that this score be used for follow-up of patients after ACL reconstruction procedure, especially with anterior knee pain related to the original objective of the Kujala score.

Reparación primaria con ancla bioabsorbible de ligamento cruzado anterior en avulsión tibial postraumática a dos años de seguimiento / Primary repair with bioabsorbable anchor of anterior cruciate ligament in post-traumatic tibial avulsion at 2 years of follow-up

Resumen: Introducción: Las lesiones del ligamento cruzado anterior son comunes; sin embargo, las avulsiones tibiales en adultos son raras. El estándar de oro continúa siendo la reconstrucción. En los últimos años se han reportado reparaciones primarias en lesiones de lado femoral mediante anclaje bioabsorbible. Caso clínico: Presentamos el caso de una reparación primaria de ligamento cruzado anterior en avulsión tibial en paciente masculino de 19 años posterior a sufrir de trauma directo con lesiones agregadas de ligamento cruzado posterior y esquina posterolateral. Se realizó reparación primaria por portal transtendón con sutura del ligamento cruzado anterior en cruz mediante FiberTape y FiberWire con anclaje SwiveLock 4.75 mm en huella tibial. Resultados: A los 24 meses de operado se encuentra con marcha independiente, arcos completos, con escalas de valoración clínica, Tegner antes de la lesión y posterior a la lesión en un nivel 6, escala de Lysholm 91, International Knee Documentation Committee (IKDC) subjetivo 73.6, IKDC objetivo en C y EQ-5D 0.79. Conclusión: Se puede reparar la avulsión de LCA en su lado tibial en ciertas condiciones con adecuada evolución y satisfacción para el paciente.

Abstract: Introduction: Anterior cruciate ligament injuries are common, however, tibial avulsions in adults are rare. The gold standard continues to be reconstruction. In recent years, primary repairs have been reported in femoral side lesions by bioabsorbable anchorage. Clinical case: We present the case of a primary repair of the anterior cruciate ligament in tibial avulsion in a patient 19 years old after presenting direct trauma with added injuries of the posterior cruciate ligament and posterolateral corner. Primary repair was performed by transtendon portal with suture of the anterior cruciate ligament with FiberTape and FiberWire and fixed with 4.75 mm SwiveLock anchor in tibial footprint. Results: At 24 months of surgery he is with independent gait, complete range of motion, with clinical assessment scales, Tegner before the injury and after the injury at a level 6, Lysholm scale 91, subjective International Knee Documentation Committee (IKDC) 73.6, objective IKDC in C and EQ-5D 0.79. Conclusion: The avulsion of ACL on its tibial side can be repaired in certain conditions with adequate evolution and satisfaction for the patient.

The Effect of Trunk Motion Control on Biomechanical Parameters of Knee During Landing / 医用生物力学

Objective To determine the effect of trunk motion control on knee biomechanics during single-leg landing. Methods Twenty male healthy basketball players were recruited. The kinematics, kinetics parameters and surface electromyogram (EMG) of knee joints under trunk motion control during single-leg landing were studied by using Vicon motion Analysis system, Kistler force platform and Noraxon surface EMG system. Results Compared with natural landing, there were significant differences in flexion angle at initial contact moment, peak flexion angle and peak flexion moment during deeply inspiratory landing and landing with a stick, and a significantly larger flexion angle at initial contact moment, a larger peak flexion angle and smaller peak flexion moment were also found. Compared with natural landing, there was no statistical difference in peak valgus angle and peak valgus moment, as well as EMG activity of hamstrings, quadriceps muscles of the knee during deeply inspiratory landing and landing with a stick. Conclusions Deeply inspiratory landing or landing with a stick reduce the risk of anterior cruciate ligament (ACL) injury, and the results provide the theoretical basis for prevention of ACL injuries in basketball players during landing.

Effects of Gender and Maneuvers on ACL Injury Risk Factors for Volleyball Players / 医用生物力学

Objective To study the effect of gender and maneuvers on anterior cruciate ligament (ACL) injury risk factors for volleyball players. Methods Sports biomechanics data of volleyball players during stop-jump, drop landing and sidestep cutting were collected. The ACL injury rate and biomechanical parameters of simulated injured jumps were obtained with Monte Carlo simulation. The influence of gender and maneuvers on ACL injury risk factors was validated by 2×3 mixed designed two-way ANOVA. Results Sidestep cutting was the highest risk maneuver of ACL injury for both genders (P＜0.001). Compared with male players, female players had a greater risk of ACL injury during sidestep cutting and stop-jump (P＜0.001), while male players were more prone to have ACL injury than female players during drop landing (P＜0.001). The risk factors of ACL injury obtained by simulation were significantly influenced by gender and maneuvers (P＜0.001). Conclusions Male players were more likely to increase ACL load due to smaller knee flexion, forward leg tilt and heel landing than female players during sidestep cutting, while female players owned larger ground reaction force (GRF) and knee extension moment. Smaller knee flexion angle during stop jump was the major risk factor for both genders, however more characteristics contributed to the males. Female players with large GRF, knee valgus and extension moment, and heel-landing were likely to have ACL injury, while the small knee flexion angle was the key risk factor for male players. The results can provide evidences for evaluation of volleyball players’ ACL injury risk, individualized injury prevention protocols, and clinical treatment and rehabilitation directions.

Kinematics and Comfortability Analysis of Orthosis for Patients Associated With Anterior Cruciate Ligament Injury: Hinge Versus Sleeve

@#Introduction: Every month, Sports National Institute (ISN) in Malaysia received around 3 to 4 cases associated with anterior cruciate ligament (ACL) injury involving athletes in hockey, kick volleyball and netball. Knee orthosis is one of treatment method and has been shown to support lower limb joint mechanics, which may protect the ACL injury for becoming worst. In this paper, an investigation was conducted to evaluate the performance of existing knee orthosis for treating ACL injury. Methods: Ten participants which have been grouped into two; six ACL patients (Group 1) and four healthy subjects (Group 2), where they took part in two bracing conditions; 1) with hinge (Brace 1) and 2) sleeve with bilateral hinges (Brace 2). A non-braced condition was included as a baseline measure. Three-dimensional kinematics data were used to calculate knee joint motions. Results: From the findings of ACL subjects, the knee flexion in non-braced condition (49.9°) has high value than others two braces, in which Brace 1 (40.9°) is less value than Brace 2 (44.6°). This shows the Brace 2 have higher degree of freedom than Brace 1. Other than that, the comfortability assessment found that Brace 2 is the most favourable options by participants in terms of less slippage and comfortless condition. Conclusion: In conclusion, the Brace 2 give best performance during dynamic balance activity in individuals who benefit from high degree of freedom and less slippage issue.

Incidence of Meniscal Tears in Cruciate Deficient Knee with Respect to Early and Delayed Reconstruction of ACL

Introduction: Descriptions of meniscus and articularcartilage lesions associated with anterior cruciate ligamentinjury have been reported by many authors. There are twoschools of thought regarding reconstruction either Earlyreconstruction and structured rehabilitation or Structuredrehabilitation with delayed reconstruction The aim of thisstudy was to identify the impact on the meniscus in earlyand delayed presentation of anterior cruciate ligament tearsand to emphasize the importance of early reconstruction ofanterior cruciate ligament to prevent further meniscal damageand articular cartilage lesions and subsequentially preventingOsteoarthritis.Materials and methods: The retrospective study wasconducted at Lourdes Hospital, Ernakulam, Kerala.Patients who presented with anterior cruciate ligament tearswere grouped into three based on their time of injury toreconstruction and the associated meniscal tears were noted.GROUP I included patients who had ACL Reconstructionwithin 2 months of injury, GROUP II within 2-6 months ofinjury and GROUP III within 6-12 Months of injury. Patientswere further divided within the groups according to their ageand grouped with a difference of ten years starting at less than25 years of age to greater than 45 years of age. Location andincidence of tear was compared between the three groupsResults: Incidence of Meniscal injury increases over timein patients as they passed through the acute, sub-acute andchronic phases of ACL deficiency. Immediately followingACL Injury Lateral meniscal injuries were more commonand was found in the acute phase (Group I). Lateral meniscustears decreased as patients passed through the acute phaseinto the sub-acute phase (Group II), whereas medial meniscaltears began to increase and predominated in the chronic phase(Group III).Conclusion: This study was able to demonstrate that theIncidence of Meniscal injury increased over time in ACLdeficient knees. Lateral meniscal injuries were more commonin acute ACL Tears. Medial meniscal injuries increased dueto instability of the knee. Hence an early Acl reconstructionpreferably within two months of injury is a good option forpatients as it prevents further meniscal damage and decreasesIncidence of Osteoarthritis.

Relationship between dynamic knee valgus and lateral trunk lean during single-leg squatting in two-dimensional image / 体力科学

Dynamic knee valgus is considered a risk factor for anterior cruciate ligament (ACL) injuries. This study identified how knee in distance (KID) and hip out distance (HOD) affect one’s lateral trunk lean (LTL). The results were also tested for reliability. Fifteen female basketball players (30 legs) from a university participated in this study. The participants performed single-leg squats by bending the knee of the supporting leg to 60°. The trials were recorded using a video camera. The KID, HOD, and LTL were measured with two-dimensional images using the Dartfish software, which measured the maximal knee valgus. The Pearson’s correlation coefficient was used to measure the correlation between dynamic knee valgus (KID and HOD) and LTL. Additionally, the Interclass Correlation Coefficient (ICC) was used to measure the reliability of the KID, HOD, and LTL data sets. The statistical significance was established at a level of p<0.05. Results showed that the KID and LTL had a significantly negative correlation, measured at r=-0.227, p<0.05. The ICC (2.1) values were: 0.83 for HOD, 0.99 for KID, and 0.96 for LTL; while the ICC (1.2) values were: 0.86 for HOD, 0.83 for KID, and 0.85 for LTL. The two-dimensional analysis technique revealed that the values were highly reliable. In sum, dynamic knee valgus had a negative correlation with LTL during single-leg squats. Therefore, it was suggested that the factors of dynamic knee valgus might be evaluated using LTL on two-dimensional screening test.

Finite Element Analysis on Biomechanical Properties of Unicompartmental Knee Arthroplasty in ACL Fracture of the Knee Joint / 医用生物力学

Department of Orthopedics, Yang Pu Hospital Affiliated to Tongji University,

Effect of electroacupuncture on rehabilitation of knee joint movement after anterior cruciate ligament reconstruction / 中国针灸

OBJECTIVE@#To observe the effect of electroacupuncture (EA) on the rehabilitation of knee joint function after anterior cruciate ligament (ACL) reconstruction.@*METHODS@#A total of 140 patients with ACL reconstruction were randomly divided into an observation group (58 cases recruited, 12 cases dropped out) and a control group (65 cases recruited, 5 cases dropped out). The patients in the control group were treated with routine rehabilitation treatment. The patients in the observation group, on the basis of the treatment in the control group, were treated with EA at Fengshi (GB 31), Futu (ST 32), Zusanli (ST 36), Shangjuxu (ST 37), Fenglong (ST 40), Xuanzhong (GB 39), Diji (SP 8) and Sanyinjiao (SP 6) on the affected side (2 Hz/100 Hz of dilatational wave, 2-5 mA). Each EA treatment lasted 20-30 min, twice a day for 7 days. The swelling degree (d), pain visual analogue scale (VAS), knee joint range of motion (ROM), scores of International Knee Documentation Committee (IKDC) subjective short form and scores of Lysholm were observed in the two groups 1 day, 1 month, 3 months, 6 months and 1 year after operation.@*RESULTS@#One month and 3 months after operation, the swelling degree (d) and VAS scores in the observation group were lower than those in the control group (0.05). One month, 3 months, 6 months and 1 year after operation, the ROM of the knee joint in the observation group was higher than that in the control group (<0.05), the IKDC score and Lysholm score were higher than those in the control group (<0.05). Within one year, there were no relaxations, fractures and other related complications in the two groups. The pivot shift test, anterior drawer test and the Lachman test were all negative.@*CONCLUSION@#EA combined with routine rehabilitation training could obviously reduce the pain of knee joint, improve the swelling degree, increase the ROM of knee joint, promote the functional recovery in patients with ACL reconstruction, which are superior to rehabilitation training alone.

Progress in Knee Joint Motion Analysis after Anterior Cruciate Ligament Reconstruction / 医用生物力学

Anterior cruciate ligament (ACL) deficiency is a common clinical injury that seriously affects the function of the knee. Although ACL reconstruction (ACLR) can rebuild the structure of the ACL, it does not restore the normal kinematics and dynamics of the knee. In recent years, motion analysis has been widely applied in sports science and rehabilitation. In clinics, motion analysis is mainly applied to the evaluation of clinical outcomes of the ACLR knee. It is also a scientific objective tool to assess the potential risk factors of secondary injury and early onset of osteoarthritis after ACLR. In-depth understanding of the knee functional kinematics and kinetics after ACLR will significantly improve the efficacy of current ACL deficiency treatment and rehabilitation regime. This paper reviewed studies of the knee joint motion analysis after ACLR in the past decade. The current knowledge of the ACLR knee motion from studies using optical motion capture and biplanar fluoroscopic imaging system based tracking technique was synthesized. Clinical studies have reported that regardless of the type of graft and surgical technique of the ACLR, the postoperative knee still exhibits abnormal kinematics in functional tasks, but the relationship between early-onset OA and the biomechanical changes in the ACLR knee remains unknown. Restoring the rotational stability of the knee is still one of the biggest challenges in clinical ACLR surgery. Future studies should explore the impact of ACLR on the biomechanical mechanisms of the knee joint through an appropriate research design and long-term follow-up, and help clinicians and physiotherapists to develop more effective interventions.

Predictors for Anterior Cruciate Ligament (ACL) Re-injury after Successful Primary ACL Reconstruction (ACLR)

@#Introduction: Few authors have addressed risk factors related to an ipsilateral graft rupture and contralateral anterior cruciate ligament (ACL) injury after return to sports (RTS) following primary ACL reconstruction. Material and Methods: Patients with ACL re-injury to either knee after successful primary ACLR were included in Group I and those with no further re-injury were included in Group II. Variables including age, gender, side, body mass index (BMI), thigh atrophy, anterior knee laxity difference between both knees measured by KT-1000 arthrometer, mean time of return to sports (RTS), graft type, type of game, mode of injury, Tegner Activity Score, hormone levels, femoral tunnel length (FTL), posterior tibial slope (PTS) and notch width index (NWI) were studied. Binary logistic regression was used to measure the relative association. Results: A total of 128 athletes were included with 64 in each group. Mean age in Group I and II were 24.90 and 26.47 years respectively. Mean follow-up of Group I and Group II were 24.5 and 20.11 months respectively. Significant correlation was present between ACL re-injury and following risk factors; PTS of >10º, KT difference of >3.0mm, thigh atrophy of >2.50cm and time to RTS <9.50 months P value <0.05). No correlation was found with age, sex, BMI, type of game, Tegner Activity Score, mode of injury, NWI, size of graft, FTL and hormone levels. Conclusion: Possible risk factors include PTS of ≥ 10º, KT difference of ≥ 3.0mm at 1 year follow-up, thigh atrophy of ≥ 2.50cm at 1 year follow-up and RTS <9.5 months after primary ACLR.

Variabilidad en la ubicación de los túneles femoral y tibial en reconstrucción del ligamento cruzado anterior. Revisión narrativa / Variability in the positioning of femoral and tibial tunnels in the reconstruction of the anterior cruciate ligament: A NARRATIVE REVIEW

Introducción Aunque los estudios detallan el origen, la forma y la inserción del ligamento cruzado anterior (LCA), no hay consenso sobre la ubicación del punto adecuado para el posicionamiento del túnel femoral y tibial en la reconstrucción. El objetivo del estudio es revisar la literatura sobre la variabilidad en el posicionamiento de los túneles femoral y tibial en la reconstrucción del LCA. Materiales y Métodos Se realizó una búsqueda sistemática y revisión narrativa de la literatura publicada en las bases Medline, Embase, Central, Cochrane y Lilacs, usando términos MesH y libres. Se realizó una selección por título y resumen y revisión de textos completos. Se clasificaron las publicaciones por temas y se hizo una presentación narrativa de los hallazgos. Resultados Se incluyeron 25 estudios. Se encontró variabilidad en la selección de áreas de origen e inserción del LCA, tanto en modelos cadavéricos como pacientes: entre los reparos anatómicos para el posicionamiento del túnel femoral están la cresta intercondilea, cresta bifurcada, cresta del residente, ubicación según el sentido de las manecillas del reloj, remanente del LCA y para el túnel tibial el cuerno anterior del menisco lateral. También hubo variabilidad en los métodos intraquirúrgicos y ayudas imagenológicas como lo son el uso del portal artroscópico antero-medial, cuadrantes de Bernard, fluoroscopio y fluoroscopio navegado. Solo un estudio evaluó la variabilidad en el posicionamiento entre y dentro de cada cirujano mostrando relativa consistencia entre ellos. Discusión El sitio de posicionamiento del túnel femoral y tibial para la reconstrucción del LCA, queda determinado por la experiencia del cirujano al no tener guías objetivamente estandarizadas, para realizar la reconstrucción.

Background Although several studies have detailed the origin, shape, and insertion of the anterior cruciate ligament (ACL), there is still no consensus on the location of the appropriate point for the positioning of the femoral and tibial tunnels for its grafting. The purpose of this study is to review the literature on the variability in the positioning of femoral and tibial tunnels when a graft reconstruction of the ACL has to be performed. Methods A systematic search was carried out on the literature published in the Medline, Embase, Central, Cochrane, and Lilacs databases, using MesH and free terms. A selection was made by title and summary and a review of complete texts. The publications were classified by topic, and a narrative presentation of the findings was made. Results A total of 25 studies were included. Variability was found in the selection of areas of origin and insertion of the ACL in both cadaveric models and patients. Among the anatomical repairs for the positioning of the femoral tunnel are the intercondylar crest, bifurcated crest, the resident's crest, clockwise or counter-clockwise direction, remnant of the ACL, and for the tibial tunnel, the anterior horn of the lateral meniscus. There was also variability in the intra-surgical methods and imaging aids, such as the use of the antero-medial arthroscopic portal, Bernard's quadrants, fluoroscope, and navigated fluoroscope. Only one study evaluated the variability in positioning between and within each surgeon, showing relative consistency between them. Discussion The positioning site of tunnels for the reconstruction is determined by the experience of the surgeon, since there are no objectively standardised guides to perform the reconstruction.