Revisiting the orbital complications of acute rhinosinusitis

Abstract Objective: The present study revisited three classification systems of orbital complications of acute rhinosinusitis (ARS) (Chandler, Mortimore & Wormald, and Velasco e Cruz & Anselmo-Lima) and observed which of them presented the best clinical applicability. Methods: Clinical data and CT scan findings of patients with orbital infection were retrospectively collected. To compare the three classification systems, we revised and graded all CT images accordingly, and divided the patients into four groups: Eyelid cellulitis (EC), orbital cellulitis (OC), subperiosteal abscess (SA), and orbital abscess (OA). The groups were compared regarding the presence of sinus opacification, the need for hospitalization and/or surgical treatment, and the presence of further complications/sequelae. Results: 143 patients were included. The median number of sinuses involved in patients in the OC, SA, and OA groups was 2.0. ARS was rarely associated with signs of EC (present in both Chandler's and Mortimore & Wormald's classifications. The hospitalization rate was significantly lower in the EC group compared to the other three groups. Surgery was performed in all cases in the OA group, in 58.1% in the SA group, 19.4% in the OC group, and 12.5% in the EC group (p-value < 0.0001 ). Complications were present at higher rates in the OA group compared to the other three groups. Conclusions: ARS was rarely associated with Eyelid Cellulitis. The stratification in the other three groups showed to be clinically relevant. Velasco e Cruz & Anselmo-Lima's classification system proved valid, simple, and effective for categorizing orbital complications of ARS. Level of evidence: 3.

How to avoid the inappropriate use of antibiotics in upper respiratory tract infections? A position statement from an expert panel / Como evitar o uso inadequado de antibióticos nas infecções de vias aéreas superiores? Posição de um painel de especialistas

Abstract Introduction: Bacterial resistance burden has increased in the past years, mainly due to inappropriate antibiotic use. Recently it has become an urgent public health concern due to its impact on the prolongation of hospitalization, an increase of total cost of treatment and mortality associated with infectious disease. Almost half of the antimicrobial prescriptions in outpatient care visits are prescribed for acute upper respiratory infections, especially rhinosinusitis, otitis media, and pharyngotonsillitis. In this context, otorhinolaryngologists play an important role in orienting patients and non-specialists in the utilization of antibiotics rationally and properly in these infections. Objectives: To review the most recent recommendations and guidelines for the use of antibiotics in acute otitis media, acute rhinosinusitis, and pharyngotonsillitis, adapted to our national reality. Methods: A literature review on PubMed database including the medical management in acute otitis media, acute rhinosinusitis, and pharyngotonsillitis, followed by a discussion with a panel of specialists. Results: Antibiotics must be judiciously prescribed in uncomplicated acute upper respiratory tract infections. The severity of clinical presentation and the potential risks for evolution to suppurative and non-suppurative complications must be taken into 'consideration'. Conclusions: Periodic revisions on guidelines and recommendations for treatment of the main acute infections are necessary to orient rationale and appropriate use of antibiotics. Continuous medical education and changes in physicians' and patients' behavior are required to modify the paradigm that all upper respiratory infection needs antibiotic therapy, minimizing the consequences of its inadequate and inappropriate use.

Resumo Introdução: A resistência bacteriana a antibióticos nos processos infecciosos é um fato crescente nos últimos anos, especialmente devido ao seu uso inapropriado. Ao longo dos anos vem se tornando um grave problema de saúde pública devido ao prolongamento do tempo de internação, elevação dos custos de tratamento e aumento da mortalidade relacionada às doenças infecciosas. Quase a metade das prescrições de antibióticos em unidades de pronto atendimento é destinada ao tratamento de alguma infecção de vias aéreas superiores, especialmente rinossinusites, otite média aguda supurada e faringotonsilites agudas, sendo que uma significativa parcela dessas prescrições é inapropriada. Nesse contexto, os otorrinolaringologistas têm um papel fundamental na orientação de pacientes e colegas não especialistas, para o uso adequado e racional de antibióticos frente a essas situações clínicas. Objetivos: Realizar uma revisão das atuais recomendações de utilização de antibióticos nas otites médias, rinossinusites e faringotonsilites agudas adaptadas à realidade nacional. Método: Revisão na base PubMed das principais recomendações internacionais de tratamentos das infecções de vias aéreas superiores, seguido de discussão com um painel de especialistas. Resultados: Os antibióticos devem ser utilizados de maneira criteriosa nas infecções agudas de vias aéreas superiores não complicadas, a depender da gravidade da apresentação clínica e dos potenciais riscos associados de complicações supurativas e não supurativas. Conclusões: Constantes revisões a respeito do tratamento das principais infecções agudas são necessárias para que sejam tomadas medidas coletivas no uso racional e apropriado de antibióticos. Somente com orientação e transformações no comportamento de médicos e pacientes é que haverá mudanças do paradigma de que toda infecção de vias aéreas superiores deva ser tratada com antibióticos, minimizando por consequência os efeitos de seu uso inadequado.

Rinossinusite aguda / Acute rhinosinusitis

Objetivos: revisar a prevalência, a etiologia, o diagnóstico e o tratamento da rinossinusite aguda. A rinossinusite aguda é uma doença comum de prevalência mundial, caracterizada por uma inflamação da cavidade nasal e dos seios paranasais, podendo ter origem fúngica, viral ou bacteriana. Os sintomas são principalmente obstrução e secreção nasal, porém a sintomatologia pode ser ampla. Consequentemente, a correta identificação e manejo torna essa patologia um desafio na prática clínica. Metodologia: Foi realizado uma busca nas bases de dados Medline/ Pubmed e LILACS no mês de maio de 2018, incluindo artigos publicados em inglês ou português nos últimos 5 anos. Foram utilizados os seguintes descritores: "acute rhinosinusitis", "rhinitis" e "sinusitis". Os artigos foram selecionados com busca direta, considerando relevância do tema à proposta e fator de impacto. Resultados: De 228 publicações, 10 foram selecionadas, demonstrando que a rinossinusite aguda é uma doença cuja incidência ainda não está bem definida, mas é maior em indivíduos com idade entre 12 e 17 anos em relação à população geral, com prevalência de etiologia viral. Conclusão: A rinossinusite aguda é uma doença com alta incidência. O diagnóstico é predominantemente clínico, mas em casos restritos há exames de imagem, sendo o tratamento sempre sintomático.

Objectives: To review the prevalence, etiology, diagnosis and treatment of acute rhinosinusitis. Acute rhinosinusitis is a common global disease characterized by inflammation of the nasal cavity and paranasal sinuses, which may be of fungal, viral or bacterial origin. The symptoms are mainly obstruction and nasal secretion, but the symptomatology can be ample. Methodology: The search was performed in the Medline / Pubmed and LILACS databases in May 2018, including articles published in English or Portuguese in the last 5 years. The following descriptors were used: "acute rhinosinusitis", "rhinitis" and "sinusitis". The articles were selected with direct search, considering relevance of the theme to the proposal and impact factor. Results: Of 228 publications, 10 were selected, demonstrating that acute rhinosinusitis is a disease whose incidence is still not well defined, but is higher in individuals aged 12 to 17 years in relation to the general population, with a prevalence of viral etiology. Conclusion: Acute rhinosinusitis is a disease with a high incidence. The diagnosis is predominantly clinical, but in restricted cases there are imaging tests, and the treatment is always symptomatic.

Costo-efectividad de furoato de mometasona tópica nasal para el tratamiento de la rinosinusitis aguda en México / Cost-effectiveness of nasal topical mometasone furoate for the treatment of acute rhinosinusitis in Mexico

Resumen Introducción: La rinosinusitis aguda (RSA) es frecuente en primer nivel de atención y los pacientes pueden mejorar sin antibióticos.Objetivo: Análisis de costo efectividad de furoato de mometasona spray nasal (FMSN) comparado con amoxicilina en tratamiento de rinosinusitis aguda en México desde punto de vista del Sistema Nacional de Salud. Método: Análisis costo-efectividad comparando FMSN 200 mg dos veces al día y amoxicilina 500 mg tres veces al día. Resultados en términos de eficacia modelados como cambios en sistema de Calificación de Síntomas Mayores (MSS por siglas inglés). MSS consiste en cinco preguntas: rinorrea, goteo retro nasal, congestión, cefalea sinusal y dolor facial. Datos clínicos obtenidos de ensayo clínico aleatorizado. Costos expresados en pesos mexicanos 2016. Se realizó análisis de sensibilidad univariable y multivariables para algunos parámetros utilizados en el modelo. Resultados: Los costos proyectados fueron de $3,261 pesos con FMSN y $3,438 pesos con amoxicilina. FMSN fue asociado con ahorro de costos por paciente de $177 pesos comparado con amoxicilina en un periodo de dos semanas. La tasa incremental de costo-efectividad del FMSN lo ubica como dominante frente a amoxicilina. El análisis de sensibilidad confirma los ahorros globales de costos y la superioridad en términos de la eficacia. Conclusión: En pacientes con rinosinusitis aguda, no complicada, el tratamiento del, FMSN 200 mcg dos veces al día, produjo mejoras significativas de los síntomas en comparación con amoxicilina en pacientes sin infecciones bacterianas y es una alternativa costo efectiva para el Sistema Nacional de Salud Mexicano. Comentario editorial al finalizar el artículo.

Abstract Introduction: Acute rhinosinusitis (RSA) is a common cause of consultation on first level of attention and it can be solved without antibiotics use. Objective: Analysis of cost effectiveness of nasal spray mometasone furoate (NSMF) compared to amoxicillin in treatment of acute rhinosinusitis in Mexico from a National Mexican Health System perspective. Methods: Cost-effectiveness analysis comparing NSMF 200µg twice daily and amoxicillin 500mg three time daily. The effectiveness outcomes of the study were modeled as changes in the Major Symptom Score (MSS). MSS consists of five questions concerning rhinorrhea, post-nasal drip, nasal congestion, sinus headache, and facial pain. Clinical data were obtained from a randomized clinical trial. Cost were expressed in Mexican pesos 2016. Sensitivity analysis was conducted univariable and multivariable for some model parameters. Results: The projected costs were $3,261 pesos with NSMF and $3,438 pesos with amoxicillin. NSMF was associated with a cost savings per patient of $177 pesos versus amoxicillin over a 2 weeks period. The incremental cost-effectiveness ratio for NSMF dominated amoxicillin. The sensitivity analysis confirms overall cost savings and superiority in terms of effectiveness. Conclusion: In patients with non-complicated acute rhinosinusitis NSMF 200 µg twice daily produce significantly an improvement in symptoms compared to amoxicillin in patients without bacterial infections and is a cost-effective alternative for the National Health Mexican System. Editorial comment at the end of this article.

Oftalmoparesia dolorosa episódica asociada a rinosinusitis aguda recurrente: un caso de síndrome de Tolosa Hunt / Painful episodic ophtalmoparesis associated to acute recurrent rhinosinusitis: a case of Tolosa Hunt Syndrome

El síndrome de Tolosa Hunt es un cuadro inflamatorio del seno cavernoso, idiopático y caracterizado por uno o más episodios de dolor orbital unilateral asociado o seguido de paresia oculomotora (afección del III, IV y VI nervio craneal) y en ocasiones con compromiso de la rama maxilar del nervio trigémino. Nosotros presentamos un hombre de 27 años con episodios de oftalmoparesia dolorosa derecha concomitantes a cuadros de rinosinusitis agudas. Su estudio fue negativo y en una de sus recurrencias se encontró en la RM de alta resolución de senos cavernosos, compromiso inflamatorio con captación de gadolinio de los nervios III, IV, V2 y VI derechos. Dado los hallazgos, se planteó el diagnóstico de STH exacerbado por la rinosinusitis e inició tratamiento corticoidal prolongado.

Tolosa Hunt Syndrome is the idiopathic inflammation of cavernous sinus, characterized by one or more episodes of unilateral orbital pain followed by ophtalmoparesis (III, IV o VI nerve palsy) and sometimes the affection of maxillary branch of the trigeminal nerve. We describe the case of a 27 years old man with episodes of painful right ophtalmoparesis associated with acute rhinosinusitis. On high resolution MRI there was inflammation of the III, IV, V2 and VI right nerves with gadolinium enhancement. We propose the THS diagnosis exacerbated by rhinosinusitis and started on chronic steroid therapy.

Acute Rhinosinusitis in Prominently Pneumatized Sphenoid Sinus Presenting with Unilateral Abducens Nerve Palsy / 대한이비인후과학회지

Acute rhinosinusitis is a rare cause of abducens nerve palsy. Most reported cases with VIth cranial nerve palsy associated sphenoid sinusitis are fungal sphenoid sinusitis, mucocele, or severe bacterial sinusitis. In this report, we present a patient with acute mild sphenoid sinusitis presented as abducens nerve palsy associated with prominent sphenoid pneumatization to the Dorello's canal.

Rinossinusite / Rhinosinusitis

A rinossinusite (RS), uma das afecções mais prevalentes das vias aéreas superiores, caracteriza-se pela inflamação da mucosa do nariz e cavidades paranasais. A classificação das rinossinusites, decorrentes de processos infecciosos virais, bacterianos e fúngicos, vem sendo sistematicamente modificada nos últimos anos, assim como os sinais, sintomas e achados de exames a serem levados em consideração para o diagnóstico. A rinossinusite aguda (RSA), infecciosa por natureza, tem duração de menos de quatro semanas, enquanto a rinossinusite crônica (RSC), com duração de mais de 12 semanas, é considerada multifatorial. Evidências crescentes na literatura mostram que a RSC representa uma resposta imunológica e inflamatória do hospedeiro em adição a uma infecção inicial. O tratamento sintomático e o seguimento compõem a estratégia inicial para pacientes com sintomas leves.

Rhinosinusitis, one of the most prevalent diseases of the upper airway, characterized by inflammation of the nasal mucosa and paranasal cavities. The classification of rhinosinusitis, due to infectious processes viral, bacterial, fungal, has been systematically modified in recent years, as well as the signs, symptoms and findings of tests to be considered for the diagnosis. The acute rhinosinusitis, infectious in nature, lasts less than four weeks, while chronic rhinosinuisitis, lasting more than 12 weeks in considered multifactorial. Mounting evidence in the literature show that CSR represents an immune and inflammatory response of the host in addition to an initial infection. Symptomatic treatment and follow up the initial strategy for patients with mild symptoms.

Complicación del drenaje endoscópico en un paciente con absceso retroorbitario: caso clínico / Complication of an endoscopic drainage on a patient with a retro-orbital abscess: report of a case

La rinosinusitis aguda, puede presentar una serie de complicaciones conocidas, un grupo de ellas son las complicaciones orbitarias. Se presenta la historia de un paciente que consultó por proptosis ocular, siendo diagnosticado un absceso subperióstico retroorbitario secundario a una rinosinusitis aguda. Se trató con técnica endoscópica, evoluciona con un hematoma retroorbitario que tuvo que ser drenado con un abordaje mixto, endoscópico y abierto, con buena evolución. Actualmente las complicaciones orbitarias de la rinosinusitis aguda tienen una baja prevalencia, y así, las complicaciones del drenaje endoscópico son aún menos frecuentes. Se destaca la importancia del conocimiento del manejo tanto endoscópico como abierto.

Among acute rhinosinusitis complications, the ones with orbital involvement are relevant. We present a case report of a patient who presented proptosis and was initially diagnosed with a retro ocular abscess as a complication to an acute rhinosinusitis. The abscess was drained with an endoscopic sinus surgery. On the fourth post-surgery day a retro ocular hematoma was diagnosed. The hematoma was treated with a combined open and endoscopic approach with a favorable outcome. In conclusion, even though orbital complications of rhinosinusitis nowadays have low prevalence, and orbital complications of their endoscopic management are even rarer, it is important for the otorhinolaryngologist to be familiar with their open, endoscopic, or combined surgical treatment.